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Zeid T. Mustafa on Muck Rack

Zeid T. Mustafa

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Articles

Reduction of secondary bile acids following microbiome pre-conditioning was associated with reduced breast cancer progression

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By Margaret S. Bohm, Johnathan R. Yarbro, Claudia Torres, Mehdi Chaib, Sydney C. Joseph, Laura Sipe, Katherine Cook, Joseph Pierre Verified, Liza Makowski, Zeid T. Mustafa, Tahliyah S. Mims, Joel H. Elasy
| Nature Verified
Abstract Breast cancer is the most common cause of cancer-related death in women worldwide. We previously reported that a primary bile acid mimetic reduced tumor progression in vivo. Here, we hypothesized that elevating primary bile acids through preconditioning of the gut microbiome may be an unexplored opportunity to improve breast cancer. We utilized the antibiotic vancomycin previously reported to deplete Gram-positive, anaerobic microbes that convert primary bile acids to secondary bile acids.
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