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Zeyue Huang on Muck Rack

Zeyue Huang

As seen in: Nature, MDPI, ACS Publications
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Articles

Chemical Proteomics Reveals a Novel Long-Acting Maleimide Algaecide Targeting Glyceraldehyde-3-Phosphate Dehydrogenase for Cyanobacterial Bloom Control Click to copy article link Article link copied!

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By Zeyue Huang, Xiuqi Hu, Lei Zeng
| ACS Publications
Abstract Click to copy section linkSection link copied! Cyanobacterial blooms pose severe threats to aquatic ecosystems and public health, driving an urgent need for targeted and environmentally benign control agents. Herein, we report a series of maleamide-based algaecides developed through phenotype-guided structural optimization. Among them, compound A4 exhibited exceptional potency against Synechocystis sp.
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Crystallographic Study Reveals a Cryptic Allosteric Site of FBPase by Sulfonylurea Inhibitors toward T2DM Treatment Click to copy article link Article link copied!

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By Zeyue Huang, Xiuqi Hu, Zheng Liu
| dx.doi.org
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Inhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an antifungal strategy - Nature Communications

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By Hongxuan Cao, Jie Tu, Jiahui Chen, Bingzhang Chen, Zeyue Huang, Yingjie Wang, Jing Shen, Xiuqi Hu, Li Rao, Zheng Liu, Nokwanda Makunga, Muhammad Hameed, Chen Su, Jian Wan, Wenqiang Chang, Chunquan Sheng, Jialin Bo, Yanliang Ren
| Nature Verified
Abstract The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogs inhibiting the interactions of ribosome assembly factor Mrt4 with rRNA to combat fungal infections. Through antifungal screening, we identified a promising lead 20 with strong efficacy against various drug-resistant fungi, including notorious super-fungus Candida auris.
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