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Jian Wan

As seen in: Color Research & Application, Nature, Wiley Online Library, PLOS ONE, Frontiers, MDPI, Taylor & Francis Online, ZDNet, ACS Publications, Medscape and
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Articles

Stiffness-Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG-TNS4 Signaling

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By Jian Wan, Xue Zhang, Biwen Zhu
| Wiley Online Library Verified
1 Introduction Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies, and liver metastasis accounts for the majority of PDAC-related deaths [1-3]. The “seed and soil” framework emphasizes that metastatic success depends not only on disseminated tumor cells but also on organ-specific microenvironments that enable seeding, survival, and outgrowth [4, 5].
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Копирование сделок торгового сигнала AI ceo для MetaTrader 4

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By Jian Wan
| mql5.com
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 0 Прибыльных трейдов: 0 (0.00%) Убыточных трейдов: 0 (0.00%) Лучший трейд: 0.00 USD Худший трейд: 0.00 USD Общая прибыль: 0.00 USD Общий убыток: 0.00 USD Макс. серия выигрышей: 0 (0.00 USD) Макс. прибыль в серии: 0.00 USD (0) Коэффициент Шарпа: 0.00 Торговая активность: n/a Макс.
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Inhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an antifungal strategy - Nature Communications

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By Hongxuan Cao, Jie Tu, Jiahui Chen, Bingzhang Chen, Zeyue Huang, Yingjie Wang, Jing Shen, Xiuqi Hu, Li Rao, Zheng Liu, Nokwanda Makunga, Muhammad Hameed, Chen Su, Jian Wan, Wenqiang Chang, Chunquan Sheng, Jialin Bo, Yanliang Ren
| Nature Verified
Abstract The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogs inhibiting the interactions of ribosome assembly factor Mrt4 with rRNA to combat fungal infections. Through antifungal screening, we identified a promising lead 20 with strong efficacy against various drug-resistant fungi, including notorious super-fungus Candida auris.
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