Zhengwei Zhang on Muck Rack

Zhengwei Zhang

As seen in: Science Magazine, Nature, Wiley Online Library, Cambridge University Press & Assessment, Frontiers, MDPI, JAMA Network, EJNMMI Research, Dialnet - Universidad de La Rioja
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Articles

Multimodal Imaging Insights Into Iatrogenic Cataract After Laser Vitreolysis

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By Zhengwei Zhang
| JAMA Network Verified
A 59-year-old male presented with a 2-week history of right eye vision loss, which developed 2 days after undergoing Nd:YAG laser vitreolysis for vitreous floaters.1 His best-corrected visual acuity (BCVA) was 20/250 OD, a reduction from his prelaser treatment BCVA of 20/40 OD. Slitlamp examination revealed extensive frostlike opacities on the posterior lens capsule and 2 suspected punched-out lesions, convex toward the nucleus, in the central and inferior quadrants (Figure, A).
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Network toxicology study and key target validation of chlorpyrifos-induced nonalcoholic fatty liver disease - Scientific Reports

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By Yapeng Li, Zhengwei Zhang, Hongji Li, Guixin Zhang, Junting Ren, Manyu Gong, Haodong Li, Shibo Sun, Ying Zhang, Xiaoning Chen
| Nature Verified
Abstract Chlorpyrifos (CPF) is a widely used insecticide known for its extended persistence in soil and water. It can induce non-alcoholic fatty liver disease (NAFLD) in mice. However, the specific molecular mechanisms responsible for CPF-induced NAFLD remain partially understood. Utilizing network toxicology analysis, we have identified TP53, HSP90AA1, AKT1, and JUN as pivotal driver genes orchestrating NAFLD progression triggered by CPF.
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Epithelial plasticity shapes intratumoral heterogeneity and cell lineages in early-stage lung cancer

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By Yu Xiao, Yatian Chen, Yoshihiro Okamura, Xiaofang Wang, Kai Yan, Ning Xin, Weiqing Li, Zhengwei Zhang, Chunling Zeng, Yuxiang Luo, Xiaoxiao Liu, Xiaojing Lu, Yue Dong, Xu Lin, Ying Li, Xiaona Jia, Simin Wang, Hua Tang, Yuexiang Wang, Yangjie Xiong, Yumei Cheng, Xinhui Yan, Haoqi Lan, Tanwen Wu
| Science Magazine Verified
Abstract Intratumoral heterogeneity (ITH) has been investigated primarily in locally advanced or metastatic cancer; however, much less is known about ITH in early-stage cancer, and the origins of ITH are poorly understood. Through single-cell and spatial transcriptomics of early-stage ground-glass opacity (GGO)–like lung adenocarcinoma (LUAD) (14 patients; 103,375 cells), we systematically define tumor states and demonstrate that pervasive transcriptional ITH exists in early-stage LUAD.
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