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Self-Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines
1 Introduction Peptide vaccines have been widely used in immunotherapy because of their high safety, biocompatibility, specificity, and structural design flexibility [1, 2], and have been applied in the treatment of neurodegenerative diseases, cancers, infectious diseases, and autoimmune diseases [3-6].
Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication
ArticleVolume 86, Issue 12p2390-2409.e17 Affiliations & Notes 1Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China 2School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China 3Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA 4Howard Hughes Medical Institute, Chevy Chase, MD, USA 5Life Sciences Institute, Zhejiang University, Hangzhou, China Article Info Publication History: Received April 16, 2025;...
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
1 Introduction Stress granules (SGs) are dynamic biomolecular condensates composed of untranslated mRNA and a variety of RNA-binding proteins (RBPs) [1-3]. Untranslated messenger ribonucleoprotein (mRNP) complexes condense into SGs through a network of protein-protein, protein-RNA, and RNA-RNA interactions between individual mRNPs [4, 5].
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