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Zhongying Guo on Muck Rack

Zhongying Guo

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Articles

SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

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By Guangping Chen, Zhongying Guo, Xiaobing Niu, Guangbo Fu
| Diagnostic Pathology Verified
Abstract Background Bladder cancer (BC) is a common and deadly disease. Over the past decade, a number of genetic alterations have been reported in BC. Bladder urothelium expresses abundant urea transporter UT-B encoded by Slc14a1 gene at 18q12.3 locus, which plays an important role in preventing high concentrated urea-caused cell injury. Early genome-wide association studies (GWAS) showed that UT-B gene mutations are genetically linked to the urothelial bladder carcinoma (UBC).
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