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Zhongying Yang on Muck Rack

Zhongying Yang

As seen in: Nature, Respiratory Research, BioRxiv, eLife, The Journal of Biological Chemistry
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Articles

Serotype-specific neutralizing activity and clinical outcomes associated with intravenous immunoglobulin in pediatric HAdV-3 and HAdV-7 infections

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By Zhongying Yang, Yanhao Huang, Heping Fang, Lifen Rao, Ying Lu, Xiangyu Liu, Jianhua Wei, Jing Liao, Luo Ren, Enmei Liu, Na Zang
| Nature Verified
Abstract Human adenovirus (HAdV) is an important cause of pediatric acute respiratory infection and severe pneumonia, with HAdV-3 and HAdV-7 being predominant respiratory serotypes. Intravenous immunoglobulin (IVIG) is empirically used in severe HAdV infection, but its serotype-specific activity remains unclear.
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Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair KATP Channel Trafficking

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By Assmaa ElSheikh, Yi-Ying Kuo, Kara E. Boodhansingh, Zhongying Yang
| BioRxiv
Abstract ATP-sensitive potassium (KATP) channels composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) couple glucose metabolism with insulin secretion in pancreatic β-cells and are vital to glucose homeostasis. Loss-of-function mutations in SUR1 and Kir6.2, encoded by ABCC8 and KCNJ11, respectively are the commonest causes of severe persistent hypoglycemia in infants and children seen in the rare disease congenital hyperinsulinism (HI).
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AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

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By Assmaa ElSheikh, Camden M Driggers, Ha Truong, Zhongying Yang
| eLife
eLife Assessment This important study demonstrates that screening by artificial intelligence can identify relevant novel compounds for interacting with KATP channels. The experimental work is compelling.
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