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Zhuoxian Meng on Muck Rack

Zhuoxian Meng

As seen in: Nature, Science Magazine, Cell Metabolism
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Articles

ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)

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By Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Ping Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Wei Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zhong, Gonglu Liu
| Nature Verified
Abstract A critical question in Duchenne muscular dystrophy (DMD) research is whether regulatory mechanisms beyond dystrophin loss contribute to impaired muscle regeneration. Through integrative analysis of proteomics and single-nucleus RNA sequencing database, we identify the upregulation of ANXA11, a gene encoding a Ca²⁺-dependent phospholipid-binding protein, in MYH3⁺ regenerative myofibers from both mdx mice and DMD patients.
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A famsin-glucagon axis mediates glucose homeostasis

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By Aijun Long, Yazhuo Wang, Yihua Guo, Jie Hong, Guang Ning, Zhuoxian Meng, Jiqiu Wang, Yiguo Wang
| Cell Metabolism Verified
Keywords famsin OLFR796 OR10P1 glucagon gluconeogenesis Get full text access Log in, subscribe or purchase for full access. References 1. Campbell, J.E. ∙ Drucker, D.J. Islet alpha cells and glucagon--critical regulators of energy homeostasis Nat. Rev. Endocrinol. 2015; 11:329-338 2. Unger, R.H. ∙ Cherrington, A.D. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover J. Clin. Invest. 2012; 122:4-12 3. Müller, T.D. ∙ Finan, B. ∙ Clemmensen, C. ...
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