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Zhi-Ying Wu

As seen in: Nature, Cell Press
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Articles

Vitamin B5 supports anti-PD1 response in HER2-positive gastric cancer and enhances interaction between naïve B cells and T cells

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By Chaoye Wang, Jing Yang, Ming-yu Lai, Jia-Chen Lu, Zhi-Ying Wu, Hai-Yan Zhang, Fang Wang, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Feng-Hua Wang, Wen-Long Guan, Ying Jin, Rui-hua Xu, QI Zhao, Miao-Zhen Qiu, Li-Qiong Yang
| Nature Verified
Abstract The cellular mechanisms underlying HER2-positive gastric cancer (HER2+ GC) responses to immunochemotherapy remain underexplored. Here, we perform longitudinal single-cell RNA-sequencing with paired TCR/BCR profiling on HER2+ and HER2-negative gastric cancer (HER2− GC) pre- and post-treatment to find dynamic immune remodeling during. Pre-treatment HER2+ GC displays an immunogenic microenvironment enriched with tumor-reactive T and B cells compared to HER2− GC.
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ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)

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By Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Ping Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Wei Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zhong, Gonglu Liu
| Nature Verified
Abstract A critical question in Duchenne muscular dystrophy (DMD) research is whether regulatory mechanisms beyond dystrophin loss contribute to impaired muscle regeneration. Through integrative analysis of proteomics and single-nucleus RNA sequencing database, we identify the upregulation of ANXA11, a gene encoding a Ca²⁺-dependent phospholipid-binding protein, in MYH3⁺ regenerative myofibers from both mdx mice and DMD patients.
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More than microglial depletion: PLX5622 activates the hepatic constitutive androstane receptor to alter anesthesia and addiction

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By Kelei Cao, Wang Cheng, Liyao Qiu, Zexi Wang, Yuqing Zhao, Ying Yuan, Weiying Wu, Jingyuan Xue, Linghui Zeng, Zhi-Ying Wu, Huan Ma, Tingjun Hou, David Hume, Cunqi Ye, Shumin Duan, Zhihua Gao
| Cell Press Verified
Keywords microglia colony-stimulating factor 1 receptor PLX5622 constitutive androstane receptor metabolism anesthesia Get full text access Log in, subscribe or purchase for full access. References 1. Paolicelli, R.C. ∙ Sierra, A. ∙ Stevens, B. ... Microglia states and nomenclature: A field at its crossroads Neuron. 2022; 110:3458-3483 2. Badimon, A. ∙ Strasburger, H.J. ∙ Ayata, P. ... Negative feedback control of neuronal activity by microglia Nature. 2020; 586:417-423 3. Cserép, C. ∙ Pósfai, B. ∙ Lénárt, N.
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