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Zhi-Ying Wu

As seen in: Nature, Cell Press
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Articles

ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)

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By Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Ping Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Wei Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zhong, Gonglu Liu
| Nature Verified
Abstract A critical question in Duchenne muscular dystrophy (DMD) research is whether regulatory mechanisms beyond dystrophin loss contribute to impaired muscle regeneration. Through integrative analysis of proteomics and single-nucleus RNA sequencing database, we identify the upregulation of ANXA11, a gene encoding a Ca²⁺-dependent phospholipid-binding protein, in MYH3⁺ regenerative myofibers from both mdx mice and DMD patients.
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More than microglial depletion: PLX5622 activates the hepatic constitutive androstane receptor to alter anesthesia and addiction

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By Kelei Cao, Wang Cheng, Liyao Qiu, Zexi Wang, Yuqing Zhao, Ying Yuan, Weiying Wu, Jingyuan Xue, Linghui Zeng, Zhi-Ying Wu, Huan Ma, Tingjun Hou, David Hume, Cunqi Ye, Shumin Duan, Zhihua Gao
| Cell Press Verified
Keywords microglia colony-stimulating factor 1 receptor PLX5622 constitutive androstane receptor metabolism anesthesia Get full text access Log in, subscribe or purchase for full access. References 1. Paolicelli, R.C. ∙ Sierra, A. ∙ Stevens, B. ... Microglia states and nomenclature: A field at its crossroads Neuron. 2022; 110:3458-3483 2. Badimon, A. ∙ Strasburger, H.J. ∙ Ayata, P. ... Negative feedback control of neuronal activity by microglia Nature. 2020; 586:417-423 3. Cserép, C. ∙ Pósfai, B. ∙ Lénárt, N.
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Biallelic SORD pathogenic variants cause Chinese patients with distal hereditary motor neuropathy

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By Hai-Lin Dong, Zhi-Ying Wu, Jia-Qi Li, Gong-Lu Liu
| Nature Verified
Abstract Sorbitol dehydrogenase gene (SORD) has been identified as a novel causative gene of recessive forms of hereditary neuropathy, including Charcot–Marie–Tooth disease type 2 and distal hereditary motor neuropathy (dHMN). Our findings reveal two novel variants (c.404 A > G and c.908 + 1 G > C) and one known variant (c.757delG) within SORD in four Chinese dHMN families.
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