Zi Wei Chia on Muck Rack

Zi Wei Chia

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Articles

Programmable antibody-based chimeric entry receptors for sarbecoviruses

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By Yidan Wang, Wilaiporn Saikruang, Kei Sato, Feng Zhu, Han Wang, Barnaby Young, Haifeng Ye, Lin-Fa Wang, Zi Wei Chia
| Nature
Abstract Despite frequent spillover of sarbecoviruses, most SARS-related viruses discovered in animals fail to engage human ACE2 (hACE2), limiting mechanistic insight and risk assessment. Here we developed antibody-based chimeric entry receptors (ABCERs) that reprogram antibody-antigen recognition into a synthetic, cell-anchored receptor interface.
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