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ZZ Zhao Zhang on Muck Rack

ZZ Zhao Zhang

As seen in: Nature, Genes and Development Journal
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Articles

Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration

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By Lauren E. Tracy, Yao Chen, ZZ Zhao Zhang
| Genes and Development Journal
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA Corresponding author: z.z{at}duke.edu ↵1 These authors contributed equally to this work. Footnotes Supplemental material is available for this article. Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.353011.125. Received May 11, 2025. Accepted October 24, 2025.
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Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

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By ZZ Zhao Zhang
| Nature Verified
Abstract Nearly half of the genome of humans and other mammals consists of transposable elements (TEs). Recent advancements in sequencing technologies have revealed that TEs have important regulatory functions, echoing Barbara McClintock’s 1950s vision of TEs as ‘controlling elements’. Nevertheless, TEs can still interfere with gene expression and are linked to various human diseases.
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