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Abstract The spleen is a central organ for systemic immune surveillance and is especially important in mouse models to study infection, vaccination, and inflammatory disease. However, a high-resolution single cell reference for the murine spleen has been lacking. Here we present a single-nucleus multiomic atlas using same-cell single-nucleus RNA-seq and single-nucleus ATAC-seq profiling of 12 adult C57BL/6 mouse spleen samples.
You are already at the latest version West Nile Virus (WNV) belongs to the orthoflavivirus genus and is part of the Flaviviridae family, which includes the Japanese encephalitis virus, Dengue virus, Zika virus, and yellow fever virus. WNV circulates among birds and mosquitoes, posing infection risks to humans and mammals.
1. Introduction Survival of the fittest is a law of evolution that applies to all entities, including viruses. Virus infection does not always translate to disease. The disease manifestation depends on persistent viral multiplication and dysregulated host immune response.
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