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Abby V McGee

As seen in: Medium, Nature, BioRxiv, Cell Press
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Articles

An integrated, scaled approach to resolve TSC2 variants of uncertain significance

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By Carina G Biar, Ziyu Wang, Nathan D. Camp, Daniel Holmes, Melinda K Wheelock, Sriram Pendyala, Abby V McGee, Pankhuri Gupta, Abbye E McEwen, Malvika Tejura, Marcy E. Richardson, Jamie D. Weyandt, Taylor Coleman, Alan Rubin, Nick Moore, Ross Stewart, Allyssa J. Vandi, Samantha J. Dawson, Predrag Radivojac, Lea M. Starita, Gemma L. Carvill, Richard James, Douglas M. Fowler, Jeffrey Calhoun, Daniel Zeiberg
| Nature Verified
Abstract Obtaining a precise genetic tuberous sclerosis complex diagnosis is a challenge as many missense TSC2 variants are variants of uncertain significance. Variants of uncertain significance in TSC2 have been resolved by one-at-a-time functional assays, but these assays cannot scale to the 3634 TSC2 missense variants of uncertain significance observed so far.
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Staking Aavegotchi

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By Abby V McGee
| Medium
Staking Aavegotchi $GHST can be likened to planting a seed and watching it sprout into a fruitful tree over time. With the right platform and tools, this digital seed can potentially grow, offering yields beyond mere appreciation. DappRadar emerges as the gardener's toolkit in this scenario, providing a user-friendly interface to stake your Aavegotchi $GHST with ease and confidence.
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Modular vector assembly enables rapid assessment of emerging CRISPR technologies

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By Abby V McGee, Yanjing V. Liu, Audrey Griffith, Zsofia Szegletes
| Cell Press Verified
Highlights • Creation of a Golden Gate-based toolkit for combinatorial CRISPR vector assembly • Development of positive control guides to enable benchmarking of CRISPR technologies • Simultaneous assessment of multiple CRISPR technologies in a pooled, barcoded setting Summary The diversity of CRISPR systems, coupled with scientific ingenuity, has led to an explosion of applications; however, to test newly described innovations in their model systems, researchers typically embark on...
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