Adelyne Chan

Correction to: Nature https://doi.org/10.1038/s41586-024-07797-z Published online 7 August 2024 In the originally published version of this article, the t-SNE plot coloured by gene expression, labelled “Cdkn1a” (p21) in Extended Data Fig. 2e, was incorrect and instead showed “Cdkn1b” (p27). This has now been corrected in the HTML and PDF versions of the article to display the appropriate Cdkn1a data. This error does not affect the text or conclusions of the study.

Highlights • COX2 is upregulated in senescence and controls expression of multiple SASP components • COX2 regulates SASP composition partly via autocrine feedback involving PGE2 and EP4 • In hepatocyte senescence, Cox2 promotes senescence surveillance and tumor suppression • Cox2 regulates the immune microenvironment of the liver, partly through PGE2 Summary Senescent cells trigger their own immune-mediated destruction, termed senescence surveillance.