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Aditi Trehan

As seen in: Cell Press, Cell Reports
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Articles

CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element

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By Peiguo Shi, Feiyue Yang, Wesley Huang, Linqing Xing, Shah Alam, Alexis O. Aparicio, Colin Kalicki, Aditi Trehan, Michael Murphy, Prajish Iyer, Lili Wang, Sara Zaccara, Muredach P. Reilly, Chaolin Zhang, Jianwen Que, Xuebing Wu, Tala FNU, Wangyang Dai, Esther R. Rotlevi
| Cell Press Verified
Keywords noncoding MYC CRISPR tiling mutagenesis ultraconserved mRNA localization cancer antisense oligonucleotides hnRNP L Get full text access Log in, subscribe or purchase for full access. References 1. The ENCODE Project Consortium An Integrated Encyclopedia of DNA Elements in the Human Genome Nature. 2012; 489:57-74 2. Elkon, R. ∙ Agami, R. Characterization of noncoding regulatory DNA in the human genome Nat. Biotechnol. 2017; 35:732-746 3.
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Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

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By Byrne S.M, Olli Pietiläinen, Aditi Trehan, Daniel Meyer
| Cell Reports Verified
Antibodies chicken anti-MAP2 Abcam Cat#ab5392; RRID:AB_2138153 Rabbit anti-Syn-1 Millipore Cat#AB1543P; RRID:AB_90757 Rabbit anti-GFAP Abcam Cat#ab16997; RRID:AB_443592 Rabbit anti-Cx43 Abcam Cat#ab230537 Goat Alexafluor plus-555- conjugated anti-mouse Thermofisher Cat#A32727; RRID:AB_2633276 Goat anti-Rabbit Alexafluor plus-488 Thermofisher Cat#A32731; RRID:AB_2633280 Experimental models: Cell lines HUES53 hESC line Eggan lab HUES53 Hes3 hESC line Eggan lab Hes3 HUES62 hESC line Eggan lab...
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A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

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By Rajat Gupta, Joseph Hadaya, Aditi Trehan, Seyedeh M Zekavat
| Cell Press Verified
Highlights • A non-coding variant on chromosome 6 associates with five vascular diseases • Histone acetylation shows a vascular-specific regulatory element at the causal SNP • Genome editing at the SNP demonstrates distal regulatory effect on endothelin-1 • Endothelin-1 signaling in blood vessels may explain pattern of vascular disease risk Summary Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease,...
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