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Adva Levy-Barda

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Articles

Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells

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By Nachum Nathan, Philipp Paparoditis, Avital Sarusi-Portuguez, Liat Stoler-Barak, Hannah Horn, Idan Milo, Roei D. Mazor, Adva Levy-Barda, Natalia Yanichkin, Nicholas Borcherding, Ronnie Blecher-Gonen, Revital Ronen, Inbal Bolocan Nachman, Inna Goliand, Liat Fellus-Alyagor, Tomer-Meir Salame, Irit Sagi, Menachem Gross, Ariel Tenenbaum, Ilan Kent, Leeat Keren, Ram Eitan, Ziv Shulman, Goni Hout Siloni, Oded Raban
| Cell Press Verified
Keywords B cells ovarian cancer germinal centers antibodies high-grade serous ovarian cancer Get full text access Log in, subscribe or purchase for full access. References 1. Perets, R. ∙ Wyant, G.A. ∙ Muto, K.W. ... Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models Cancer Cell. 2013; 24:751-765 2. Dubeau, L. ∙ Drapkin, R. Coming into focus: the nonovarian origins of ovarian cancer Ann. Oncol. 2013; 24:viii28-viii35 3.
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Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells

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By Nachum Nathan, Philipp Paparoditis, Avital Sarusi-Portuguez, Liat Stoler-Barak, Hannah Horn, Idan Milo, Roei D. Mazor, Adva Levy-Barda, Natalia Yanichkin, Nicholas Borcherding, Ronnie Blecher-Gonen, Revital Ronen, Inbal Bolocan Nachman, Inna Goliand, Liat Fellus-Alyagor, Tomer-Meir Salame, Irit Sagi, Goni Hout Siloni, Menachem Gross, Ariel Tenenbaum, Ilan Kent, Leeat Keren, Oded Raban, Ram Eitan, Ziv Shulman
| Cell Press Verified
Keywords B cells ovarian cancer germinal centers antibodies high-grade serous ovarian cancer Get full text access Log in, subscribe or purchase for full access. References 1. Perets, R. ∙ Wyant, G.A. ∙ Muto, K.W. ... Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models Cancer Cell. 2013; 24:751-765 2. Dubeau, L. ∙ Drapkin, R. Coming into focus: the nonovarian origins of ovarian cancer Ann. Oncol. 2013; 24:viii28-viii35 3.
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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

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By Keren Baranes-Bachar, Inez Myers Laboratory, Adva Levy-Barda, Judith Oehler
| Cell Press Verified
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning: the E3/E4 ubiquitin ligase UBE4A. UBE4A’s recruitment to sites of DNA damage is dependent on primary E3 ligases in the DDR and promotes enhancement and sustainment of K48- and K63-linked ubiquitin chains at these sites.
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