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Diego Adhemar Jaitin on Muck Rack

Diego Adhemar Jaitin

As seen in: Nature, Cell Press
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Articles

Localized PD-1 CAR T therapy reprograms neuroinflammation

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By Rotem Shalita, Maya Ben Yehuda, Chamutal Gur, Sarah McGrath, Vasyl Eisenberg, Shir Shlomi-Loubaton, Adin Tofield, Mor Zada, Anna Kurilovich, Eyal David, Diego Adhemar Jaitin, Kfir Mazuz, Roberto Avellino, Reut Tzemach, Yuri A. Kuznetsov, Liat Fellus-Alyagor, Adva Levy-Barda, Sarah Mundt, Rina Rosenzweig, Bettina Schreiner, Christine Stadelmann, Pascale Zwicky, Florian Ingelfinger, Ido Amit, Yasmin Frid, Roni Suhler, Lihi Bolokan, Karin Vardy, Adi Wilf Yarkoni
| Cell Press Verified
Keywords multiple sclerosis autoimmunity single-cell genomics deep probabilistic modeling immunotherapy CAR T cells follicular Th cells PD-1 IL-10 enhancer-driven regulatory circuits Get full text access Log in, subscribe or purchase for full access. References 1. Attfield, K.E. ∙ Jensen, L.T. ∙ Kaufmann, M. ... The immunology of multiple sclerosis Nat. Rev. Immunol. 2022; 22:734-750 2. Hemmer, B. ∙ Kerschensteiner, M. ∙ Korn, T.
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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By Michelle von Locquenghien, Pascale Zwicky, Ken Xie, Diego Adhemar Jaitin, Fadi Sheban, Adam Yalin, Florian Uhlitz, Chamutal Gur, Eyal David, Kfir Mazuz, Caroline Jennings Marin, Ankita Sankar, Devin Mediratta, Roberto Avellino, Assaf Weiner, Ido Amit
| Cell Press Verified
Keywords cancer immunotherapy myeloid checkpoints tumor-associated macrophages cytokines tumor-microenvironment modulation TREM2 TME-conditional IL-2 myeloid-targeted immunocytokine T and NK cell synergy single-cell genomics synthetic immunology Get full text access Log in, subscribe or purchase for full access. References 1. Sharma, P. ∙ Hu-Lieskovan, S. ∙ Wargo, J.A. ... Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy Cell. 2017; 168:707-723 2.
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Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

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By Yonatan Katzenelenbogen, Fadi Sheban, Adam Yalin, Ido Yofe, Dmitry Svetlichnyy, Diego Adhemar Jaitin, Chamutal Bornstein, Hadas Keren-Shaul, Merav Cohen, Shuang-Yin Wang, Baoguo Li, Eyal David, Tomer-Meir Salame, Assaf Weiner, Ido Amit, Adi Moshe
| ScienceDirect Verified
Highlights • INs-seq: a new technology for recording scRNA-seq and intracellular protein activity • INs-seq defines new immune subsets by TF combinations and metabolic activity • Mapping Arg1+ cells within tumors reveals novel Trem2+ suppressive myeloid cells • Genetic ablation of Trem2 decreases Mreg, exhausted CD8+ T cells and tumor growth Summary Cell function and activity are regulated through integration of signaling, epigenetic, transcriptional, and metabolic pathways.
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