Agatheeswaran Subramaniam

Abstract Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human disease.

ELM2 domain is present in a diverse set of chromatin associated proteins such as RCOR1-3, MTA1-3, MIER1-3 and RERE ( Millard et al., 2014 Millard C.J. Fairall L. Schwabe J.W. Towards an understanding of the structure and function of MTA1. ). Hence, to identify essential regions that may confer sensitivity to UM171, we aligned ELM2 sequences from proteins known to contain ELM2.

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws Ludwig Schmiderer, Agatheeswaran Subramaniam, Kristijonas Žemaitis, Alexandra Bäckström, David Yudovich, Svetlana Soboleva, Roman Galeev, Christelle N. Prinz, Jonas Larsson, Martin Hjort Proceedings of the National Academy of Sciences Aug 2020, 202001367; DOI: 10.1073/pnas.2001367117