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Akira Nishii on Muck Rack

Akira Nishii

As seen in: PLOS Biology, Science Magazine, The Journal of Clinical Investigation, American Journal of Managed Care, The Journal of Biological Chemistry

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Articles

Lamin A/C regulates lipid metabolism and inflammation: insights from models of familial partial lipodystrophy 2

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By Jessica N. Maung, Rebecca L. Schill, Akira Nishii, Bonje N. Obua
| The Journal of Clinical Investigation
ResearchClinical ResearchMetabolism Open Access | 10.1172/JCI198387 J Clin Invest. https://doi.org/10.1172/JCI198387. Copyright © 2025, Maung et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Familial partial lipodystrophy 2 (FPLD2) is a rare disease characterized by adipose tissue loss and redistribution, and metabolic dysfunction.
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BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice

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By Steven M. Romanelli, Kenneth Lewis, Akira Nishii
| The Journal of Biological Chemistry Verified
CRISPR/Cas9 has enabled inducible gene knockout in numerous tissues; however, its use has not been reported in brown adipose tissue (BAT). Here, we developed the brown adipocyte CRISPR (BAd-CRISPR) methodology to rapidly interrogate the function of one or multiple genes. With BAd-CRISPR, an adeno-associated virus (AAV8) expressing a single guide RNA (sgRNA) is administered directly to BAT of mice expressing Cas9 in brown adipocytes.
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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures

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By Hiroyuki Mori, Colleen E. Dugan, Akira Nishii
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Hiroyuki Mori , Colleen E. Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S. Cadenhead IV, Arun K. Das, Charles R. Evans, Katherine A. Overmyer, Steven M. Romanelli, Sydney K. Peterson, Devika P. Bagchi, Callie A. Corsa, Julie Hardij, Brian S. Learman, Mahmoud El Azzouny, Joshua J. Coon, Ken Inoki, [ ... ], Ormond A. MacDougald [ view all ] [ view less ] Hiroyuki Mori, Colleen E. Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S.
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