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Articles

Karyopharm To Stick With Blood Cancers As Xpovio Flops In Endometrial Cancer

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By Alaric DeArment Verified
| Scrip Verified
The company plans file for the drug’s approval in myelofibrosis in August and to continue developing it in multiple myeloma. Following the failure of Xpovio (selinexor) in endometrial cancer, Karyopharm Therapeutics is shifting the focus for the drug’s development to myelofibrosis, where it plans to seek US Food and Drug Administration accelerated approval based on mixed results from a Phase III study.
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Alnylam Lowers 2026 TTR Guidance As Amvuttra Forecast Comes Back To Earth

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By Alaric DeArment Verified
| Scrip Verified
The company lowered its TTR franchise sales guidance for 2026 by $200m, with the chief financial officer admitting the original guidance “didn’t get it right.” Alnylam Pharmaceuticals’ Amvuttra (vutrisiran) for cardiomyopathy due to wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) reached an important milestone as it had the first quarter in which its sales exceeded $1bn. But the company nevertheless revised its guidance for 2026 downward, prompting a fall in its share price.
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Caldera, Synlogic Reverse Merge To Develop CLD-423 In Inflammatory Bowel Disease

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By Alaric DeArment Verified
| Scrip Verified
The new company, under the Caldera name, is developing the TL1AxIL-23p19-targeting bispecific to avoid the immunogenicity that anti-TL1A antibodies often cause. Caldera and Synlogic are doing a reverse merger.
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