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Alawi Habara

As seen in: Nature, MDPI, Blood
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Articles

Multi-omics analysis of a pig-to-human decedent kidney xenotransplant - Nature

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By Eloi Schmauch, Brian D. Piening, Alexa K. Dowdell, Maedeh Mohebnasab, Alexey Stukalov, Ian Jaffe, Jacqueline I. Kim, Tal Eitan, Darragh O’Brien, Alexandra Bartlett, Francesca Zanoni, David Andrijevic, Berk Maden, Weimin Zhang, Loren Gragert, Lauren Hamilton, Larisa Kagermazova, Brendan Camellato, Sarah J. Gao, Alawi Habara, Scott Thomas, Deepak Saxena, Adriana Heguy, Michael Snyder, Asim Rais Siddiqui, Anita S. Chong, Minna Kaikkonen, Suvi Linna-Kuosmanen, Massimo Mangiola, Ramin S Herati, Jeffrey S. Stern, Adam D. Griesemer, Manolis Kellis, Jef Boeke, Robert Montgomery
| Nature Verified
Abstract Organ shortage remains a major challenge in transplantation, and gene-edited pig organs offer a promising solution1–3. Despite gene-editing, the immune reactions following xenotransplantation can still cause transplant failure4. To understand the immunological response of a pig-to-human kidney xenotransplantation, we conducted large-scale multi-omics profiling of the xenograft and the host’s blood over a 61-day procedure in a brain-dead human (decedent) recipient.
Open in Who Shared Issue with article?

Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching

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By Alawi Habara
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Integrative multi-omics profiling in human decedents receiving pig heart xenografts - Nature Medicine

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By Brian D. Piening, Maedeh Mohebnasab, Bo Xia, Jeffrey S. Stern, Weimin Zhang, Jacqueline I. Kim, David Andrijevic, Karen Abou Khalil, Ian Jaffe, Darragh O’Brien, Han Chen, Andrew Chang, Xiangping Lin, Alawi Habara, Feng-Xia Liang, Adriana Heguy, Basil Michael, Minna Kaikkonen, Nader Moazami, Ramin S Herati, Adam D. Griesemer, Manolis Kellis, Michael Snyder, Jef Boeke, Alexa K. Dowdell, Suvi Linna-Kuosmanen
| Nature Verified
Abstract In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection.
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