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Articles by Albert Smith
An integrated germline and somatic genomic model for coronary artery disease
Abstract Multiple germline and somatic genomic factors are associated with risk of coronary artery disease, but there is no single measure of risk that integrates all information from a DNA sample. To address this gap, we develop an integrated genomic model that includes six germline and somatic genetic drivers for coronary artery disease, including polygenic risk score, genetically-proxied proteomic/metabolomic risk scores, and clonal hematopoiesis of indeterminate potential.
Deflection of Buried Pipes
The Plate Com. of the American Iron and Steel Inst. sponsored research to improve methods of predicting ring deflection of buried, large-diameter pipes subjected to external soil pressure. A simple relationship was found between ring deflection, the predicted vertical soil strain, and the stiffness ratio, which generally confirms theory but is simpler, is more accurate, and establishes statistical confidence levels.
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations - Nature Communications
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Abstract Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are frequent mediators of CH. However, recent analyses of both single cell-derived colonies of hematopoietic cells and population sequencing cohorts have revealed CH frequently occurs in the absence of known driver genetic lesions.
By Joshua Weinstock, Sharjeel Chaudhry, Paula Reventun, Cecelia Laurie, Jai Broome, Xiuqing Guo, Patricia A. Peyser, Nathalie Chami, Bruce M. Psaty, Jennifer Brody, Jeong Yun, Michael Cho, Ramachandran S. Vasan, Jennifer Smith, Laura M. Raffield, Jerome I. Rotter, Stephen S. Rich, C. Gu, Chao A. Hsiung, Charles Kooperberg, Rami Nassir, Alex P. Reiner, Vijay Sankaran, Charles J. Lowenstein, Albert Smith, Pradeep Natarajan, Siddhartha Jaiswal, Alexander Bick, Paul Scheet, Paul L. Auer, Alexis Battle, Hyun M. Kang
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Nature
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ROCKEYE and Datums AI Set New Horizons for Enterprises in Indonesia
Solving Enterprise Challenges in Indonesia with the power of ROCKEYE and Datums AI Jigar Joshi Hosting the Event ROCKEYE and Datums AI deliver AI driven, scalable ERP solution, empowering Indonesian enterprises to achieve smarter, faster, and secure digital transformation. SOUTH JAKARTA CITY, JAKARTA, INDONESIA, September 3, 2025 /EINPresswire.com/ -- Indonesia, the largest digital economy in Southeast Asia, is at a pivotal moment.
AI Tools Are Strengthening Global Supply Chains
One thing that we have covered a lot in Smart Data Collective is how artificial intelligence helps businesses protect and improve supply chains. You can see clear changes across industries as companies turn to AI to reduce disruptions, increase reliability, and prepare for demand swings. Businesses around the world are expected to pay $244.22 billion on AI for various reasons this year.
AI Helps Businesses Develop Better Marketing Strategies
AI is changing how marketers plan and share content across platforms. A growing number of teams now depend on it to keep up with constant demand for fresh material. Of those already using it, 93% say it helps them get content out the door faster. It do save time, even if the end product sometimes needs tweaking. The push toward shorter turnaround times makes this kind of tool hard to ignore. Across the board, 94% of organizations now rely on AI in some stage of their marketing process.
AI Improves Integrity in Corporate Accounting
We have written about some of the ways AI can help in the financial sector. One way is by improving financial integrity in corporate accounting. Artificial intelligence is playing a growing role in upholding accuracy and transparency in corporate accounting. From identifying irregularities to automating reconciliations, these tools offer support where manual oversight may fall short.
FERTILIZACIÓN E INOCULACIÓN DE MICORRIZAS EN PLÁNTULAS DE Pinus radiata D. Don
Ayuda Buscar en la ayuda Buscar en la ayuda FERTILIZACIÓN E INOCULACIÓN DE MICORRIZAS EN PLÁNTULAS DE Pinus radiata D. Don Moreto Velásquez, Albert Smith [1] ; Samaniego Huamán, Osmer Leodan [1] ; Córdova Rojas, Lizbeth Maribel [2] ; Campos Ruiz, Joseph [3] ; Chávez Collantes, Azucena [3] ; Campos Ruiz, Sanderson Narcizo [4] [1] Facultad de Ingeniería Forestal y Ambiental, Universidad Nacional de Jaén, Jaén, Perú.
Data Analytics Proves Benefits of Strategic Domain Use
Some of the benefits of data analytics are very obvious. We have talked about some of the ways that marketers are using data analytics technology to forecast trends and better understand the nuances of their customer demographics. This is one of the reasons that companies around the world plan to spend over $6.3 billion on data analytics this year. However, there are other ways that data analytics technology can help businesses.
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate - Nature Aging
Abstract Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only correlates with age but also confers increased risk of morbidity and mortality. Here, we leverage genetically predicted traits to identify factors that determine CHIP clonal expansion rate.
"Association of low-frequency and rare coding variants with information" by Jan Bressler, Gail Davies et al.
Abstract Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Revenue Models for AI-Powered Mobile Apps
Mobile artificial intelligence is becoming more popular every day. In 2022, the market for AI in mobile development . AI has in many ways. One of the benefits of AI is that it offers personalized experiences that are tailored to individual users. Through machine learning algorithms, apps can analyze user behavior, preferences, and patterns to deliver targeted content, recommendations, and notifications.
Securing the Digital Frontier: Effective Threat Exposure Management
AI technology is radically changing the direction of the cybersecurity sector. Companies around the world are expected to in 2032 alone. Artificial Intelligence (AI) plays a pivotal role in enhancing cybersecurity measures due to its ability to rapidly analyze vast amounts of data and identify patterns that may indicate potential threats. With the proliferation of digital technologies, cyber threats have become increasingly sophisticated, making traditional cybersecurity approaches less effective.
Data Migration Salesforce: What is it and How Does it Help?
In Salesforce data migration, the source data’s size, format, and accuracy will determine the difficulty level. In data migration, data is transferred from one system to another, but the most difficult part is the work that takes place before the actual transfer. Importance of PreparationHigh-Level RequirementsData ReviewDealing with ExceptionsMapping DocumentData ContractTo Sum Up Professionals have spent time thinking about what makes data migration successful.
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification - Nature Genetics
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Abstract Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population.
By Maryam Kavousi, Haojie Lu, Chani J. Hodonsky, Joris Deelen, Xiuqing Guo, Leo-Pekka Lyytikäinen, Albert Smith, Maggie A. Stanislawski, Jessica van Setten, Lisa R. Yanek, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Michal Mokry, Jennifer Smith, Themistocles L. Assimes, J. Jeffrey Carr, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon Hingorani, M. Arfan Ikram, Ivana Isgum, Gerard Pasterkamp, Helena Schmidt Verified, P. Eline Slagboom, André G. Uitterlinden, Joshua C. Bis, Bruce M. Psaty, Jerome I. Rotter, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Kumar Malhotra
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Nature
Verified
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease - Nature Genetics
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Abstract Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective treatments. We carried out a genome-wide association study (GWAS) meta-analysis of imaging (n = 66,814) and diagnostic code (3,584 cases versus 621,081 controls) measured NAFLD across diverse ancestries.
By Annapurna Kuppa, Mary F. Feitosa, Lawrence F. Bielak, Xiuqing Guo, Vincent L. Chen, Albert Smith, Kathleen Ryan, John Carr, Yii-Der I. Chen, Antonino Oliveri, Adolfo Correa, Jill M Norris, Jerome I. Rotter, Brian Halligan, Kendra A Young, Vilmundur Gudnason, Michael A. Province, Nicholette D. Palmer
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Nature
Verified
Genetic insights into resting heart rate and its role in cardiovascular disease - Nature Communications
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Method details Populations The full RHR meta-analysis included 100 studies with data on RHR in up to 835,465 individuals. RHR was obtained from ECG in 54 studies, from pulse rate in 31 studies (of which seven were self-measured by the participants), from blood pressure monitor in nine studies, from electronic medical records in three studies, from manual measurement in one study and through a combination of multiple of the before mentioned methods in two studies.
By Yanick Hagemeijer, Albert Smith, Claudia Schurmann, Jennifer Brody, Gardar Sveinbjornsson, Cécile Lecoeur, Aaron Isaacs, Jian’an Luan, Anne Jackson, Lawrence F. Bielak, Maria Nethander, Wei Zhao, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Raymond Noordam, Stella Trompet, Stefan Weiss, Xueling Sim, Ilja M. Nolte, Leo-Pekka Lyytikäinen, Lenore J. Launer, Susan M. Ring, Allan Linneberg, Bruce M. Psaty, Daniel F. Gudbjartsson, Hilma Holm, Beverley Balkau, Christopher Newton-Cheh, Patricia A. Peyser, Heribert Schunkert, Jari Lahti, Jennifer Smith, Maria Pina Concas, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Kent Taylor, Luisa Foco, Åsa Johansson, Peter K. Joshi, Peter W. Macfarlane, Kirill V. Tarasov, Harold Snieder, Johan Ormel, Andrew Morris, Torben Frøstrup Hansen, Themistocles L. Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C. Morrison, Patricia B Munroe, David P. Strachan, Niels Grarup, Susan R. Heckbert, Philippe Froguel, Leif Groop, Nicholas J Wareham, Mary F. Feitosa, Michael Boehnke, Jeanette Erdmann, Claes Ohlsson, David Porteous, Claude Bouchard Verified, Susanne Moebus, Peter Kraft, David R. Weir, Luigi Ferrucci, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, Jaspal S Kooner, Jerome I. Rotter, Andrew Hicks, Ulf Gyllensten, James WIlson, James Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J. Wouter Jukema, Ching-Yu Cheng, Marcus Dörr, Charumathi Sabanayagam, Albertine J. Oldehinkel, Terho Lehtimäki, Claes Ladenvall
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Nature
Verified
Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule
Rugged Energy Landscapes Describe the Apo and Ghrelin-Bound State of GHSR In order to connect the above results describing reorientational dynamics to the sampling of distinct structures of GHSR, we performed a PCA of the GHSR backbone (N, C′, Cα). PCA separates translational motion in the MD trajectory into statistically independent modes, and sorts them from largest absolute variance to smallest, allowing one to determine the largest modes of motion for the apo and ghrelin-bound MD simulations.
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis - Nature
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Abstract Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2,3,4,5,6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling.
By Joshua Weinstock, Bala Bharathi Burugula, Mesbah Uddin, Bence Daniel, Shaneice Mitchell, Cecelia Laurie, Joshua Lewis, Kathleen C. Barnes, Myriam Fornage, Susan Redline, Brian E. Cade, Bruce M. Psaty, Joshua C. Bis, Jennifer Brody, Nicholette D. Palmer, Michael Cho, Ramachandran S. Vasan, Lisa R. Yanek, Patricia A. Peyser, Michiel Rienstra, Susan R. Heckbert, Nicholas Smith, Kerri L. Wiggins, Michael Cutler, Stacey Knight, Adolfo Correa, Stephen S. Rich, Peter M Nilsson, Brian Custer, Joanne Curran, John Blangero, Stephen T. McGarvey, Gregory M Marcus, Dawood Darbar, Charles Kooperberg, Andrew Johnson, Rasika A. Mathias, NHLBI Trans-Omics, Albert Smith, Ansuman T. Satpathy, Pradeep Natarajan, Jacob O. Kitzman, Eric A. Whitsel, Alexander Bick, Jayakrishnan Gopakumar, Taralynn M. Mack, Clive R. Pullinger
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Nature
Verified
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program - Nature Communications
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Abstract Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown.
By Adrienne M. Stilp, Bjarni V Halldorsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Min-Zhi Jiang, Fritz J Sedlazeck, Joshua B. Bis, Nathalie Chami, Wonji Kim, Lisa R. Yanek, John Blangero, Michael Cho, Joanne Curran, Myriam Fornage, Joshua Lewis, Alanna C. Morrison, Michael Preuss, Bruce M. Psaty, Stephen S. Rich, Hua Tang, Albert Smith, Andrew Johnson, Rasika A. Mathias, Matthew P. Conomos, Magnus Magnusson, Nathan Pankratz, Daniel Bauer, Paul L. Auer
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Nature
Verified
10 Principles to Attain Success in Modern Business
Work hard, play hard is the mantra for success that is given to budding entrepreneurs. But in the 21st century, no single rule can be applied to it. You might even have heard people saying, “Don’t simply work hard, work smart.” There are endless motivational and inspirational videos of successful businesses and of people who can go on and on with their advice. The thing is that success has different meanings for different people and even takes different paths depending upon its pursuer.
Localized and collective motions in HET‐s(218‐289) fibrils from combined NMR relaxation and MD simulation
Communication Localized and collective motions in HET‐s(218‐289) fibrils from combined NMR relaxation and MD simulation Beat H Meier Corresponding Author E-mail address: beme@ethz.ch ETH Zürich, Department of Physical Chemistry, Wolfgang-Pauli-Strasse 10, 8093 Zürich, SWITZERLAND Search for more papers by this author PDF PDF Share Abstract Nuclear magnetic resonance (NMR) relaxation data and molecular dynamics (MD) simulations are combined to characterize the dynamics of the fungal prion...
albert smith's Page
The Press Photo History Project Mapping the photo agencies and photographers of Fleet Street and the UK UAL Photography and Photography and the Archive Research Centre Royal Photographic Society's Historical Group www.londonstereo.com London Stereoscopic Company / T. R. Williams www.earlyphotography.co.uk British camera makers and companies Fox Talbot Museum, Lacock. National Portrait Gallery, London http://www.freewebs.com/jb3d/ Alfred Seaman and the Photographic Convention Frederick Scott Archer
Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms
Progress and future challenges in aging and diversity research in the United States
Frontispiece: Because the Light is Better Here: Correlation-Time Analysis by NMR Spectroscopy
AbstractNMR Spectroscopy In their Communication on page?13590, M. Ernst, B.?H. Meier, and A.?A. Smith examine potential pitfalls for the NMR analysis of protein dynamics and propose the use of dynamics detectors to characterize different ranges of correlation times.
Because the Light is Better Here: Correlation-Time Analysis by NMR Spectroscopy
Relaxation data in NMR spectra are often used for dynamics analysis, by modeling motion in the sample with a correlation function consisting of one or more decaying exponential terms, each described by an order parameter, and a correlation time. This method has its origins in the Lipari–Szabo model-free approach, which originally considered overall tumbling plus one internal motion and was later expanded to several internal motions.
Albert Smith, 1925-2016
Albert Smith, 90, of Columbia, entered into the Master’s paradise on Saturday, April 9, 2016, at Boone Hospital Center. He was born Sept. 24, 1925. Albert Smith, 90, of Columbia, entered into the Master’s paradise on Saturday, April 9, 2016, at Boone Hospital Center. He was born Sept. 24, 1925. Funeral services will be held at noon Saturday, April 16, at St. Luke United Methodist Church.
ALBERT FRANKLIN SMITH - Lawrence County Record : Obituaries
He was preceded in death by one sister, Betty Smith; and two brothers, Harvey and Charley Smith. Survivors include his wife, Patricia; three sons, Albert Smith, Jr., Niangua, Benny Smith, Camdenton, and Jeffrey Smith, Marshfield; a daughter, Pamela Keith, Marionville; two brothers, Jonas Smith, Pontiac, and Curtis Smith, Salem, Ark.; one sister, Mary White, Theodosia; 16 grandchildren; and 35 great grandchildren. Funeral services were March 31 Fraker Funeral Home, Marshfield.
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium
Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores.
White Matter Lesion Progression
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Background and Purpose—White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
By Ian Ford Verified, Thomas Lumley, Meike W Vernooij, Albert Hofman, Albert Smith, Alexa S. Beiser, Qiong Yang, Sudha Seshadri, Charles DeCarli, Philippe Amouyel, Sigurdur Sigurdsson, Vilmundur Gudnason, Joshua C. Bis, Myriam Fornage, M. Arfan Ikram, Thomas Mosley, Rebecca Gottesman, Bruce M. Psaty, Rudi Westendorp, Brendan Buckley Verified, Hieab H. H. Adams, Edith Hofer, Margherita Cavalieri, Velandai Srikanth, Stella Trompet, Benjamin F. J. Verhaaren, Christiane Wolf, Michele Callisaya, Ganesh Chauhan, Carole Dufouil, Paul Freudenberger, Gerardo Heiss, Oliver Martinez, Bernard Mazoyer, Wiro J. Niessen, Thanh Phan, Claudia L. Satizabal, Naveed Sattar, Sabrina Schilling, Dean K. Shibata, P. Eline Slagboom, David J. Stott, Russell Thomson, Anna M. Töglhofer, Christophe Tzourio, Mark van Buchem, B. Gwen Windham, Alex Zijdenbos, Richard Beare, Stéphanie Debette, J. Wouter Jukema, Lenore J. Launer, Helena Schmidt Verified, Chris Moran, Kent Taylor
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stroke.ahajournals.org
Effectiveness of Prompts on Fourth-Grade Children’s Dietary Recall Accuracy Depends on Retention Interval and Varies by Gender
Background: Dietary recall accuracy is related to retention interval (RI) (i.e., time between to-be-reported meals and the interview), and possibly to prompts. To the best of our knowledge, no study has evaluated their combined effect. Objective: The combined influence of RI and prompts on children’s recall accuracy was investigated in this study.
Artist Spotlight: Lyle Ashton Harris
Ever since he was born in the Bronx, N.Y., Lyle Ashton Harris has split his time between New York and some far-off land. As a boy, it was Dar es Salaam, Tanzania. Now he lives and works in New York City and Accra, Ghana. His work has been exhibited internationally, including at the Guggenheim Museum and the Whitney Museum of American Art. Harris's work is regularly featured in a wide range of publications, including The New York Times Magazine, Vibe, and New York.
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