Alberto Bardelli
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Adaptive plasticity in targeted therapy
Get full text access Log in, subscribe or purchase for full access. References 1. Patelli, G. ∙ Tosi, F. ∙ Amatu, A. ... Strategies to tackle RAS-mutated metastatic colorectal cancer ESMO Open. 2021; 6, 100156 2. Prahallad, A. ∙ Sun, C. ∙ Huang, S. ... Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR Nature. 2012; 483:100-103 3. Amodio, V. ∙ Yaeger, R. ∙ Arcella, P. ... EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer Cancer Discov.
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets
Author contributions Conceptualization, C.R.J. and T.G.; samples, B.A.W., B.S., C.S., D.d.J., D.K.-L., D.N., E.G., G.J.L.H.v.L., G.K., H.W.M.vL., I.V.B., J.C., J.L., J.N.M.I., J.P.M., J.P.P.M., J.W.M.M., M.F.B., M.L., M.M., M.Y., N.C.T.v.G., R.D.M.S., R.E.K., R.H.B., T.L., T.Y.S.L.L., V.C., W.v.H., J.J., and X.Z.; methodology, B.S., J.L., M.L., R.R.d.G.-d.H., S.R.P., and T.S.; software, J.C.K., M.L., and T.V.P.; validation, M.L. and T.V.P.; formal analysis, A.V.-M., A.H., F.B., F.R., I.V.B.,...
Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models
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Keywords cytotoxic chemotherapy immune surveillance chemotherapy cisplatin temozolomide colorectal cancer neoantigens immune checkpoint blockade immune rewiring mismatch repair modulation Introduction Immune checkpoint blockade (ICB) with programmed cell death protein 1 (PD-1) ± cytotoxic T lymphocyte antigen 4 (CTLA-4) blocking antibodies has shown efficacy in colorectal cancers (CRCs) characterized by either deficient mismatch repair (MMRd) or inactivating mutations in the proofreading...
By Pietro Paolo Vitiello, Benoit Rousseau, Rosaria Chilà, Vito Amodio, Gaia Grasso, Achille Anselmo, Francesca Clemente, Giuseppe Rospo, Simona Lamba, Alice Bartolini, Federica Pisati, Claudio Tripodo, Noemi Congiusta, Mariangela Russo, Giovanni Crisafulli, Federica Di Nicolantonio, Giovanni Germano, Luis Diaz, Alberto Bardelli, Paolo Battuello, Vittorio Battaglieri, Sharon Scardellato
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Cell Press
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