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Aldwin Suryo Rahmanto

As seen in: Cell Press
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Articles

RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

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By Shubo Zhao, Chloe S Palma-Chaundler, Carla M. Engel, Jacqueline Cordes, Daniel Nixdorf, Michael Luo Verified, Selay Kaya, Aldwin Suryo Rahmanto, Diana van den Heuvel, Timur Mackens-Kiani, Pedro Weickert, Simon Lam, Vipul Gupta, Julia Philippou-Massier, Ivan Bagarić, Jonathan Bohlen, Graeme Hewitt, Martijn S. Luijsterburg, Roland Beckmann, Petra Beli, Danny D. Nedialkova, Christopher J. Carnie, Marion Subklewe, Stephen Jackson, Julian Stingele
| Cell Press Verified
ArticleVolume 86, Issue 7p1275-1292.e12Open access Affiliations & Notes 1College of Basic Medical Sciences, Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130012, China 2Gene Center, Ludwig-Maximilians-Universität München, 81377 Munich, Germany 3Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany 4Cancer Research UK Cambridge Institute,...
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PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

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By Henrik J. Johansson, Marcela Franco, Oliver Frings, Janne Lehtiö, Juha K. Rantala, Lars-Gunnar Larsson, Andrä Brunner, Aldwin Suryo Rahmanto, Johanna Viiliäinen, Mohiuddin Gazi, Erik Fredlund, Charles Spruck, Olle Sangfelt
| eLife
Abstract Inhibition of WEE1 kinase by AZD1775 has shown promising results in clinical cancer trials, but markers predicting AZD1775 response are lacking. Here we analysed AZD1775 response in a panel of human breast cancer (BC) cell lines by global proteome/transcriptome profiling and identified two groups of basal-like BC (BLBCs): ‘PTEN low’ BLBCs were highly sensitive to AZD1775 and failed to recover following removal of AZD1775, while ‘PTEN high’ BLBCs recovered.
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