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Alejo E. Rodriguez-Fraticelli on Muck Rack

Alejo E. Rodriguez-Fraticelli

As seen in: Nature, Science Magazine, BioRxiv, Cell Stem Cell, RAC 1
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Articles

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

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By Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtech Kumpost, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Ian Ghezzi, Susanne Lux, Pablo Hernández-Malmierca, Dominik Vonficht, Marta Lopez-Osias, Daniel Fernández-Pérez, Anna Mathioudaki, Judith B. Zaugg, Alejo E. Rodriguez-Fraticelli, Ralf Mikut, Andreas Trumpp, Thomas Hofer, Daniel Hübschmann, Simon J. Haas, Michael D. Milsom, Foteini Fotopoulou, Jeyan Jayarajan, Julia Knoch, Megan Druce, Kleo Aurich, Marleen Büchler-Schäff, Julius Gräsel, Elvira González-Saiz
| Nature Verified
Abstract Haematopoietic stem cells (HSCs) display extensive molecular and functional heterogeneity. However, a cohesive model that explains the relationship and biological relevance of these diverse HSC states remains elusive.
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Charting single-cell lineages with synthetic and natural barcodes

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By Alejo E. Rodriguez-Fraticelli, Victoria Parreno
| Nature Verified
Abstract Across our lifespan, cells divide and differentiate to create the functional units of all organs, yet with age and cancer a small number of cellular families (clones) will rule the fate of the organism. Advances in synthetic and natural barcoding methods now enable cellular ancestries to be reconstructed with unprecedented single-cell resolution.
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Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature

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By Michael Scherer Verified, Indranil Singh, Martina Braun, Pedro Sanchez, Pedro Sánchez, Dominik Lindenhofer, Niels Asger Jakobsen, Verena Körber, Michael Kardorff, Pauline Kautz, Julia Ruhle, Robert Frömel, Sergi Beneyto-Calabuig, Caleb A Lareau, Ansuman T. Satpathy, Renée Beekman, Leif S. Ludwig, Paresh Vyas, Alejo E. Rodriguez-Fraticelli
| Nature Verified
Abstract Current approaches used to track stem cell clones through differentiation require genetic engineering1,2 or rely on sparse somatic DNA variants3,4, which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity.
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