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Caleb A Lareau on Muck Rack

Caleb A Lareau

As seen in: Nature, Genome Biology, BioRxiv, Cell Press, eLife, Cancer Discovery, Texas Medical Center
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Articles

Patient-partnered multiomics reveals the molecular architecture of angiosarcoma

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By Hoyin Chu, Brittany A Borden, Christopher Reilly, Beena S. Thomas, Erica Pimenta, Seunghun Han, Sabrina Y. Camp, Riaz Gillani, Jacob Gutierrez, Caleb A Lareau, Matthew Nagy, Jeremy Johnson, Lauren Sterlin, Delia Sosa, Ilan Small, Mary McGillicuddy, Nouf Abdullah Alharbi, Jason L. Hornick, Hani Choudhry, Diane Diehl, Eliezer Van Allen, Nikhil Wagle, Corrie A. Painter, Saud H. AlDubayan, Marissa Hollyer, Kolbe Phelps, Oyin Alao, Hadley Grundman, Will Terzi, Elana Anastasio, Parker Chastain, Priyanka Bhakhri
| Nature Verified
Abstract Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating transcriptomic, somatic, and germline variant data, we find that subcutaneous angiosarcomas frequently exhibit TGF-β and receptor tyrosine kinase signaling upregulation, with driver mutations in KDR, PLCG1, and POT1.
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Clonal lineage tracing of innate immune cells in human cancer

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By Vincent Liu, Katalin Sandor, Patrick K. Yan, Zhuang Miao, Yajie Yin, Robert R. Stickels, Andy Chen, Kamir J. Hiam-Galvez, Jacob Gutierrez, Wenxi Zhang, Sairaj M. Sajjath, Raeline Valbuena, Steven Wang, Bence Daniel, Leif S. Ludwig, Brooke E. Howitt, Caleb A Lareau, Ansuman T. Satpathy
| Cell Press Verified
To establish a lineage tracing method applicable to donor-matched solid tissue and blood samples and to clonally link immune cells across tissue sites, we applied mtscATAC-seq to profile five patients with early-stage non-small cell lung cancer (NSCLC) who had undergone therapeutic lobectomy, spanning adenocarcinoma (SU-L-002, SU-L-004, SU-L-005; treatment-naïve), squamous cell carcinoma (SU-L-001; post-neoadjuvant chemotherapy), and neuroendocrine (SU-L-003) histologies (Figures 1A and S1A;...
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Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics

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By Yu-Hsin Hsieh, Pauline Kautz, Lena Nitsch, Ambre Giguelay, Veronika Dimitrova, Stephania Contreras Castillo, Gábor Zsurka, Genevieve Trombly, Markus Schuelke, Wolfram S Kunz, Caleb A Lareau, Leif S. Ludwig, Janet Liebold, Freya Jungen
| Nature Verified
Abstract Mitochondrial DNA (mtDNA) mutations occur more frequently than nuclear mutations and are associated with various diseases. While single-cell sequencing enables mtDNA variant heteroplasmy analysis, a holistic view of mtDNA mutational landscapes in individual cells has remained limited.
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