Alexia Tyler King

Keywords astrocyte reactivity astrocyte development neuroinflammation cellular neuroscience MHC class II human astrocytes Get full text access Log in, subscribe or purchase for full access. References 1. Allen, N.J. ∙ Bennett, M.L. ∙ Foo, L.C. ... Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors Nature. 2012; 486:410-414 2. Stogsdill, J.A. ∙ Ramirez, J. ∙ Liu, D. ... Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis Nature.

ArticleVolume 114, Issue 13p2331-2346.e7 Affiliations & Notes 1Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA 2Emory Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA 3Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA 4Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA Article Info Publication History: Received May 22, 2025; Revised December 5,...

Highlights • We engineer models to investigate the neurological manifestations of PMM2-CDG • hiPSC-derived neural models mimic neurological manifestations of PMM2-CDG • We report on changes in neural function and metabolic dynamics • We suggest potential avenues for treating the neurological symptoms of PMM2-CDG Summary Phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is a rare inborn error of metabolism caused by deficiency of the PMM2 enzyme, which leads to impaired...