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Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial

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By Wungki Park, Catherine A. O’Connor, Joanne F. Chou, Marc Hilmi, Zeynep Tarcan, Carly Schwartz, Mary Larsen Verified, Karthigayini Sivaprakasam, Shigeaki Umeda, Maria Perry, Anna Varghese, Fiyinfolu Balogun, Alice Zervoudakis, Seth Katz, Tae-Hyung Kim, Ken Zhao, Allison Richards, Nicolas Lecomte, Daniel Muldoon, Walid K. Chatila, Jessica Yang, Devika Rao Verified, Smita Joshi, Michael Foote, James Harding Verified, Andrew Epstein, David P. Kelsen, Fergus Keane, Joshua D. Schoenfeld, Anupriya Singhal, Erin DiGuglielmo, Chaitanya Bandlamudi, Junmin Song, Haochen Zhang, Maria Teresa Lao, Jerry P Melchor, Ronak Shah, Wenfei Kang, Francesca Mazzoni, Kevin C. Soares, Ernesto Santos, Vineet S. Rolston, Marsha Reyngold, Alice Wei, Murray J. Tipping, Olca Basturk, Michael Berger, Mark Schattner, William R. Jarnagin, Nadeem Riaz, Vinod P. Balachandran, Dana Pe’er, Marinela Capanu, Eileen M. O’Reilly, Ramzi Homsi, Elias Karnoub, Imane El-Dika, Ryan Sugarman, Sree Chalassani, Hulya Sahin Ozkan, Junguei Hong, Agustin III Cardenas, Mark TA Donoghue, Richard Kihn Do, Christine Iacobuzio-Donahue
| Nature Verified
Abstract Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum chemotherapy and PARP inhibition in pancreatic cancer (PC) and may enable prolonged disease control with immune checkpoint blockade (ICB). The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib following platinum-based chemotherapy in biomarker-stratified metastatic PC.
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