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Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial
Abstract Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum chemotherapy and PARP inhibition in pancreatic cancer (PC) and may enable prolonged disease control with immune checkpoint blockade (ICB). The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib following platinum-based chemotherapy in biomarker-stratified metastatic PC.
When Radiotherapy and Immunotherapy Dance-Who Leads So as Not to Step on Toes?
Original Investigation Association of Radiation Therapy With Risk of Adverse Events in Patients Receiving Immunotherapy Mitchell S. Anscher, MD; Shaily Arora, PharmD; Chana Weinstock, MD; Anup Amatya, PhD; Pradeep Bandaru, PhD; Chad Tang, MD; Andrew T. Girvin, PhD; Mallorie H. Fiero, PhD; Shenghui Tang, PhD; Rachael Lubitz, BA; Laleh Amiri-Kordestani, MD; Marc R. Theoret, MD; Richard Pazdur, MD; Julia A. Beaver, MD Full Text Full Text
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