|
Abstract Small nuclear RNAs (snRNAs) combine with specific proteins to generate small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. U4 snRNA forms a duplex with U6 and, together with U5, contributes to the tri-snRNP spliceosomal complex. Variants in RNU4-2, which encodes U4, have recently been implicated in neurodevelopmental disorders.
By Mathieu Quinodoz, Kim Rodenburg, Karolina Kaminska Verified, Suzanne de Bruijn, Ana Belén Iglesias-Romero, Mukhtar Ullah, Nick Zomer, Marc Folcher, Jacques Bijon, Lara K Holtes, Stephen Tsang, Zelia Corradi, K. Bailey Freund, Stefanida Shliaga, Daan Panneman, Rebekkah J. Hitti-Malin, Manir Dan Ali, Sten Andreasson, Gavin Arno, Galuh Astuti, Carmen Ayuso, Eyal Banin, Tahsin Stefan Barakat, Mirella Barboni, Miriam Bauwens, Tamar Ben-Yosef, Virginie Bernard, David Birch, Pooja Mittal Biswas, Fiona Blanco-Kelly, Béatrice Bocquet, Camiel Boon, Kari Branham, Dominique Brémond-Gignac, Alexis Ceecee Britten-Jones, Kinga M. Bujakowska, Elizabeth L Cadena, Giacomo Calzetti, Francesca Cancellieri, Luca Cattaneo, Naomi Chadderton, Peter Charbel Issa, Stephen P. Daiger, Elfride De Baere, Marieke De Bruyne, Julie De Zaeytijd, Ronny Derks, Claire-Marie Dhaenens, Lubica Dudakova, Jacque L. Duncan, G. Jane Farrar, Nicolas Feltgen, Beau J. Fenner, Lidia Fernández-Caballero, Simone Gana, Alejandro Garanto, Jessica Gardner Verified, Christian Gilissen, Kensuke Goto, Sam Griffiths-Jones, Tobias B. Haack, Lonneke Haer-Wigman, Alison Hardcastle, Takaaki Hayashi, Elise Heon, Lies H. Hoefsloot, Alexander Hoischen, Carel B. Hoyng, Chris F Inglehearn, Takeshi Iwata, Brynjar O. Jensson, Kaylie Jones, Vasiliki Kalatzis, Marianthi Karali, Ulrich Kellner, Caroline C. W. Klaver, Robert K. Koenekoop, Susanne F. Kohl, Taro Kominami, Laura Kühlewein, Tina M. Lamey, Bart P. Leroy, Petra Liskova, Irma Ribbon Lopez, Irma Hernández López, Omar A. Mahroo, M. Pilar Martin-Gutierrez, Nelson Martins, Laura Mauring, Martin McKibbin, Terri L. McLaren, Isabelle Meunier, Michel Michaelides, Jose Millan, Kei Mizobuchi, Rajarshi Mukherjee, Zoltan Zsolt Nagy, Kornelia Neveling, Monika Ołdak, Yang Pan, Anastasia Papachristou, Antonio Percesepe, Maximilian Pfau, Eric Pierce, Raj Ramesar, Francis Ramond, Florence Rasquin, Gillian I. Rice, Lisa Roberts, María Rodríguez-Hidalgo, Javier Ruiz-Ederra, Ataf H. Sabir, Ana Isabel Sánchez-Barbero, Asodu Sandeep Sarma, Riccardo Sangermano, Margherita Scarpato, Dror Sharon, Sabrina Signorini, Francesca Simonelli, Ana Berta Sousa, Maria Stefaniotou, Kari Stefansson, Katarina Stingl, Akiko Suga, Patrick Sulem, Lori Sullivan, Viktória Szabó, Jacek P. Szaflik, Gita Taurina, Carmel Toomes, Viet Tran, Miltiadis Tsilimbaris, Veronika Vaclavik, Marie Vajter, Sandra Valeina, Enza Maria Valente, Casey Valentine, Rebeca Valero, Mattias Van Heetvelde, Andrea L. Vincent, Andrew Webster Verified, Laura Whelan, Bernd Wissinger, Kazutoshi Yoshitake, Juan C Zenteno, Roberta Zeuli, Theresia Zuleger, Chaim Landau, Allan Jacob, Siying Lin, Winston Lee, Jamie M. Ellingford, David Stanek, Susanne Roosing, Zuzana Cvackova, Erica G. M. Boonen, Ala’a AlTalbishi, Georg Ansari, Radha Ayyagari, Sandro Banfi, Luísa Coutinho-Santos, Berta de la Cerda, John N. De Roach, Juliana M. Ferraz Sallum, Roser Gonzàlez-Duarte, Josephine P. Holtan, Smaragda Kamakari, Krisztina Knézy, Rina Leibu, Quinten Mahieu, Gaël Manes, Luke Mansard, Michiel Oorsprong, Ai Fujita Sajiki, Cristina M. Santos, Hendrik P. N. Scholl, Alberta A. H. J. Thiadens, Pavlina Tsoka, Sophie Valleix, Joseph van Aerschot, L. Ingeborgh van den Born, Virginie J. M. Verhoeven, Georgia G. Yioti, Frans P. M. Cremers
|
Nature
Verified