Alus M Xiaoli

Abstract Hepatocytes are organized along a spatial axis between the portal triad and the central vein to form functionally repetitive units known as lobules. The hepatocytes perform distinct metabolic functions depending on their location within the lobule. Single-cell analysis of hepatocytes across the liver lobule demonstrates that gluconeogenic gene expression is relatively low in the fed state and gradually increases in the periportal hepatocytes during the initial fasting period.

Abstract The liver acts as a master regulator of metabolic homeostasis in part by performing gluconeogenesis. This process is dysregulated in type 2 diabetes, leading to elevated hepatic glucose output. The parenchymal cells of the liver (hepatocytes) are heterogeneous, existing on an axis between the portal triad and the central vein, and perform distinct functions depending on location in the lobule.

Yuling Chi * Corresponding Author; email: 1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States 2The Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, United States *, Dou Yeon Youn 1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States 2The Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, United States , Alus M.