Kosaku Shinoda

Abstract A pro-tumorigenic role for adipocytes has been identified in breast cancer, and reliance on fatty acid catabolism found in aggressive tumors. The molecular mechanisms by which tumor cells coopt neighboring adipocytes, however, remain incompletely understood. Here, we describe a direct interaction linking tumorigenesis to adjacent adipocytes.

Keywords thermogenesis UCP1-independent Ca2+ cycling energy balance obesity Introduction The principle of thermogenesis follows Joule’s first law: Q (J) = I2 × R × T, where I is current, R is resistance, and T is time.1 This formula explains how proton uncoupling of the mitochondrial electron transport chain (ETC) by uncoupling protein 1 (UCP1) leads to thermogenesis in brown and beige adipocytes.

Abstract Hepatocytes are organized along a spatial axis between the portal triad and the central vein to form functionally repetitive units known as lobules. The hepatocytes perform distinct metabolic functions depending on their location within the lobule. Single-cell analysis of hepatocytes across the liver lobule demonstrates that gluconeogenic gene expression is relatively low in the fed state and gradually increases in the periportal hepatocytes during the initial fasting period.