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Abstract Atopic diseases associated with allergens, as well as allergic diseases, frequently arise early in life; however, the age-dependent mechanisms governing immune responses to allergens remain poorly understood1. Here we find that in early life, exposure to common allergens triggers a distinct bifurcated immune response, simultaneously triggering type 17 inflammation in the skin and initiating canonical T helper 2 sensitization in the lymph nodes.
Keywords lymphatic vessels lymphangiogenesis lymph node metastasis interferon gamma immune surveillance immune checkpoint blockade melanoma metabolism oxidative phosphorylation Get full text access Log in, subscribe or purchase for full access. References 1. Morton, D.L. ∙ Thompson, J.F. ∙ Cochran, A.J. ... Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma N. Engl. J. Med. 2014; 370:599-609 2. Zahoor, S. ∙ Haji, A. ∙ Battoo, A. ...
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.