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Amberley Prince

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Articles

Cellular heterogeneity in hypertrophic burn scars in response to carbon dioxide laser therapy

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By Yung-Yi Chen, Christopher B. Mahony, Jason Turner Verified, Charlotte Smith, Claudia Roberts, Adam Croft, Yvonne Wilson, Naiem S. Moiemen, Janet Lord, Abdulrazak Abdulsalam, Ezekwe Amirize, Amberley Prince, Adrian Heagerty
| Nature Verified
Abstract Ablative fractional carbon dioxide (AFCO2) laser therapy is used for treating pathological scarring. However, mechanisms underlying reduction in hypertrophic scarring are poorly understood. We investigated cellular mechanisms of AFCO2 laser therapy by performing single-cell RNA sequencing (scRNA-seq) on skin biopsies from burn survivors with hypertrophic scars before and after three sessions of AFCO2 therapy. Scar reduction was assessed subjectively and objectively.
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