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Anbarasu Kumaraswamy on Muck Rack

Anbarasu Kumaraswamy

As seen in: The Journal of Clinical Investigation, The Journal of Biological Chemistry, European Urology
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Articles

PROX1 is an early driver of lineage plasticity in prostate cancer

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By Zhi Guang Duan, Mingchen Shi, Anbarasu Kumaraswamy, Dong Lin, Yong Huei Wang, Chao Zhang, Diana Flores, William K. Storck, Hannah Beck, Radhika Patel, Erolcan Sayar, Brian Hanratty, Hui Xue, Xin Dong, Dhruv Khokhani, Eva Rodansky, Olivia A. Swaim, Zoe R. Ma
| The Journal of Clinical Investigation
Abstract Lineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a neuroendocrine prostate cancer (NEPC) program (i.e., double-negative prostate cancer [DNPC]), and AR-null NEPC tumors. Factors upregulated early in lineage plasticity are not well-characterized.
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LSD1 promotes prostate cancer cell reprogramming by repressing TP53 signaling independently of its demethylase function

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By JCI Insight, Anbarasu Kumaraswamy, Zhi Guang Duan, Diana Flores
| The Journal of Clinical Investigation
ResearchIn-Press PreviewOncology Open Access | 10.1172/jci.insight.167440 JCI Insight. https://doi.org/10.1172/jci.insight.167440. Copyright © 2023, Kumaraswamy et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cancer cell survival, including in prostate cancer.
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Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer

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By Anbarasu Kumaraswamy, Thomas Westbrook, Joel A. Yates
| European Urology Verified
Ferlay J. Colombet M. Soerjomataram I. et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019; 144: 1941-1953 Montgomery R.B. Mostaghel E.A. Vessella R. et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008; 68: 4447-4454 Cancer Genome Atlas Research N The molecular taxonomy of primary prostate cancer. Cell. 2015; 163: 1011-1025 Robinson D.
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