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Anders Mälarstig

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Articles by Anders Mälarstig

Proteogenomics in human populations

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By Ranran Zhai, Anders Mälarstig, Xia Shen
| Nature Verified
Abstract In human population studies, proteogenomics integrates genomic and proteomic data to uncover how genetic variation shapes protein expression and function. A central focus of proteogenomics is the identification of protein quantitative trait loci (pQTL), which link genetic variants to protein abundance and offer critical insights into the molecular basis of disease.
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The genetic landscape of neuro-related proteins in human plasma - Nature Human Behaviour

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By Jiantao Chen, Zhijian Yang, Ranran Zhai, Xiao Feng, Ting Li, Denis Maslov, Anna N. Timoshchuk, Sebastian May-Wilson, Marisa D. Muckian, Charles Kooperberg, Robert F. Hillary, Eleanor Wheeler, Lu Pan, Shahzad Ahmad, Sarah Harris, Nicholas J Wareham, Cecilia Lagging, Mohammad Arfan Ikram, Mikael Landén, Claudia Langenberg, Ian J Deary, Riccardo E Marioni, Sodbo Sharapov, Adam S. Butterworth, Anders Mälarstig, James WIlson, James Wilson, Pau Navarro, Linda Repetto, Fengyu Tu, Andreas Göteson
| Nature Verified
Abstract Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.
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Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation - Nature Communications

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By Anders Mälarstig, Leo Dahl, Marios Dimitriou, per eriksson, Jochen Schwenk, Cecilia E. Thomas, Tzu-Hsuan Huang
| Nature Verified
Abstract Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk.
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Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets - Nature Immunology

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By Niclas Eriksson, Erin Macdonald-Dunlop, Stefan Enroth, Domenico Cozzetto, Lasse Folkersen, Christian Herder, Christian Gieger, Dirk S. Paul, Barbara Thorand, Michael Roden, Caroline Hayward, Åsa Johansson, Ulf Gyllensten, Oskar Hansson, Peter K. Joshi, Leonid Padyukov, Lars Klareskog, Mikael Landén, James WIlson, James Wilson, Anders Mälarstig, Adam S. Butterworth
| Nature Verified
Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01588-w, published online 10 August 2023. In the version of the article originally published, the middle panel in Fig. 3b was mistakenly a duplicate of the upper panel. The figure has now been corrected in the HTML and PDF versions of the article.
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Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets - Nature Immunology

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By Niclas Eriksson, Erin Macdonald-Dunlop, Stefan Enroth, Domenico Cozzetto, Lasse Folkersen, Christian Herder, Christian Gieger, Dirk S. Paul, Barbara Thorand, Michael Roden, Caroline Hayward, Åsa Johansson, Ulf Gyllensten, Oskar Hansson, Peter K. Joshi, Leonid Padyukov, Lars Klareskog, Mikael Landén, James WIlson, James Wilson, Anders Mälarstig, Adam S. Butterworth
| Nature Verified
Abstract Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans).
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An atlas of genetic scores to predict multi-omic traits - Nature

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By Yu Xu, Scott Ritchie, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Sebastian May-Wilson, Carles A. Foguet, Åsa Johansson, Elodie Persyn, James Peters, Bram P. Prins, Jian’an Luan, Nicole Soranzo, E. Shyong Tai, Dirk S. Paul, Christopher W. H. Yau, Robert Gerszten, Anders Mälarstig, Xueling Sim, Claudia Langenberg, James WIlson, James Wilson, Adam S. Butterworth
| Nature Verified
Abstract The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1.
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Webinar | Proteogenomic strategies to advance drug development and precision medicine

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By Anders Mälarstig, Ulf Gyllensten
| Science Magazine Verified
The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases. As the end products and biological effectors of gene expression, proteins are crucial for improving our understanding of human biology, developing new and better drugs, and advancing precision medicine.
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