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Sodbo Sharapov on Muck Rack

Sodbo Sharapov

As seen in: Nature, medRxiv, Aging
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Articles

Hundreds of cardiac MRI traits derived using 3D diffusion autoencoders share a common genetic architecture

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By Sara Ometto, Soumick Chatterjee, Andrea Vergani, Arianna Landini, Sodbo Sharapov, Edoardo Giacopuzzi, Alessia Visconti, Emanuele Bianchi, Federica Santonastaso, Emanuel Soda, Francesco Cisternino, Carlo Andrea Pivato, Francesca Ieva, Emanuele Di Angelantonio, Nicola Pirastu, Craig A Glastonbury
| Nature Verified
Abstract Biobank-scale imaging provides an unprecedented opportunity to characterise how thousands of organ phenotypes vary in populations. However, deriving specific phenotypes from imaging data requires time-consuming expert annotation, limiting scalability. In this study, we develop a 3D diffusion autoencoder to derive latent phenotypes from temporally resolved cardiac MRI data of 71,017 UK Biobank participants.
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The genetic landscape of neuro-related proteins in human plasma - Nature Human Behaviour

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By Jiantao Chen, Zhijian Yang, Ranran Zhai, Xiao Feng, Ting Li, Denis Maslov, Anna N. Timoshchuk, Sebastian May-Wilson, Marisa D. Muckian, Charles Kooperberg, Robert F. Hillary, Eleanor Wheeler, Lu Pan, Shahzad Ahmad, Sarah Harris, Nicholas J Wareham, Cecilia Lagging, Mohammad Arfan Ikram, Mikael Landén, Claudia Langenberg, Ian J Deary, Riccardo E Marioni, Sodbo Sharapov, Adam S. Butterworth, Anders Mälarstig, James WIlson, James Wilson, Pau Navarro, Linda Repetto, Fengyu Tu, Andreas Göteson
| Nature Verified
Abstract Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.
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A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

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By Sodbo Sharapov, Anna N. Timoshchuk, Olga Zaytseva, Denis Maslov
| medRxiv
Y.S.A. is a full-time employee of GSK PLC and receives salary and stock options as compensation. Y.S.A. is a founder and co-owner of PolyKnomics BV, a private organization, providing services, research and development in the field of computational and statistical genomics. G.L. is a founder and owner of Genos Ltd, a biotech company that specializes in glycan analysis and has several patents in the field. O.Z., T.S., F.V. and I.T.-A are employees of Genos Ltd.
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