Andre Barbosa
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A Parametric Computational Framework for Modeling and Seismic Design of Post-Tensioned Mass Timber Rocking Walls
1 Introduction The seismic design and performance assessment of building structures has historically relied on the development of archetype buildings, which are representative structural configurations that bridge the gap between individual case studies and generalized predictions for entire structural classes [1, 2].
SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia - Nature Communications
Abstract Rare loss-of-function (LoF) mutations in SETD1A are associated with schizophrenia (SCZ). However, how SETD1A haploinsufficiency leads to SCZ-associated phenotypes and its relevance to patients without these rare mutations is unknown. Here, we identify SETD1A bound loci and regulated genes in human prenatal cortex and isogenic pluripotent stem cell-derived neuronal models engineered with SETD1A LoF variants, including the most common patient mutation.
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