Hunter Giles

Abstract Rare loss-of-function (LoF) mutations in SETD1A are associated with schizophrenia (SCZ). However, how SETD1A haploinsufficiency leads to SCZ-associated phenotypes and its relevance to patients without these rare mutations is unknown. Here, we identify SETD1A bound loci and regulated genes in human prenatal cortex and isogenic pluripotent stem cell-derived neuronal models engineered with SETD1A LoF variants, including the most common patient mutation.

Spotify‚Äôs annual Loud & Clear report is a masterclass in cherry picked stats and mythmaking. ‚ÄúStreaming‚Äôs Rising Tide‚ÄĚ goes the headline this year. ‚ÄúThe system we‚Äôve built together is working.‚ÄĚ Ok, working for who?

Abstract Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have focused on the prefrontal cortex.