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Articles by Andre Koch
Hypermethylation in CpG-rich cfDNA fragments enables accurate detection of circulating tumor DNA in BRCA1 - and BRCA2 -associated breast and ovarian cancer
Abstract Pathogenic BRCA1 and BRCA2 germline variants confer an increased risk of hereditary breast and ovarian cancer (HBOC). In this high-risk cohort, novel biomarkers are needed to support patient management. While circulating cell-free DNA-based conventional CpG-level averaging is promising, it dilutes tumor-specific signals in samples with low circulating tumor DNA (ctDNA) fractions.
A Cohort of 469 Mayer-Rokitansky-Küster-Hauser Syndrome Patients-Associated Malformations, Syndromes, and Heterogeneity of the Phenotype
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Inhibition of cervical cancer cell growth by non-thermal atmospheric plasma application utilizing a thermal argon plasma source
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Introduction: The intraepithelial neoplasia of the cervix (CIN) is a serious precursor of invasive cervical cancer (CC). Non-thermal atmospheric plasma (CAP) application might be a promising tool for low-invasive treatment of tumoral and pretumoral lesions of the cervix without requirement of local or general anaesthesia and hospitalization.
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures
Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signaling, preventing anaphase until all chromosomes are properly attached to spindle microtubules. Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit its kinase activity.
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures
Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signalling, preventing anaphase until all chromosomes are properly attached to spindle microtubules. Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit its kinase activity.
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