Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by André Mateus
Systematic profiling of growth interactions in human gut microbiome species
Abstract Microbial interactions shape the composition and stability of the human gut microbiome. Yet, few studies have systematically investigated species-species growth interactions and the mechanisms behind these. Here we show that among 36 representative gut bacterial strains, when two species interact, the interactions are mostly inhibitory.
METTL3 regulates exocytosis independently of m 6 A
|
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract RNA modification pathways are often misregulated in various cancers, with N6-methyladenosine (m6A) having a pivotal role in cancer progression and metastasis.
By Pascal J. Schmidt, Neha Chetlangia, Pin-Kuan Chiang, Margalida Esteva-Socias, Cyrinne Achour, Poonam Baidya, Kanchan Kumari, Kerstin Seier, Hudson Pace, Sandhya Malla, Shaochun Zhu, Eva Lundin, Marta Bally, Vinay Swaminathan, André Mateus, Ruth Rodríguez-Barrueco, Andreas Pich, Francesca Aguilo, Devi Prasad Bhattarai, Gaia Fontanari, Cathrine Broberg Vågbø
|
Science Magazine
Verified
Tunable TriPcides suppress virulence factor secretion during Staphylococcus aureus infection and kill dormant cells
|
Abstract Antimicrobial resistance (AMR) in common bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), is an increasingly dire public health threat, with MRSA accounting for up to 90% of S. aureus infections. To expand the treatment arsenal against MRSA infections, we developed a class of tunable three-dimensional tricyclic 2-pyridones, termed TriPcides, that can kill MRSA resistant to last-resort antibiotics and eliminate MRSA persister cells.
By Valdemar Priebe, Peter Sheridan Dodds, Mohammad A Saad, Hasan Tükenmez, Taylor Nye, Pardeep Singh, Aaron Mychack, Mari Bonde, Suzanne Hickerson, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Shaochun Zhu, Souvik Sarkar, Jaideep B. Bharate, Ingeborg van der Lingen, Anh Quoc Ntuyenm, V. U. Bhaskara Rao, Anders Lindgren, Hanna Klein, Zongsen Zou, Karen W. Dodson, Suzanne Walker, André Mateus, Jörgen Johansson, Michael G. Caparon
|
Science Magazine
Verified
Men who have sex with men newly diagnosed with HIV-1 in Portugal (2023–2024): a comparative analysis of transmission clusters between migrants and non-migrants
Abstract Migration to Europe has been rising in recent years and is associated with higher HIV vulnerability due to overlapping social and structural barriers. New cases among migrants have been steadily increasing, and for the first time in Portugal, there were more cases among migrants than among non-migrants in 2023.
Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex - Nature Communications
Abstract Eukaryotic ribosome biogenesis proceeds from nucleolus to cytosol assisted by various assembly factors. The process is evolutionarily conserved across eukaryotes but differences between the kingdoms are emerging. Here, we describe how the OPENER (OPNR) protein complex is required for 60S ribosome assembly in the model plant Arabidopsis thaliana.
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics
Abstract Studying the pathogenesis of human-adapted microorganisms is challenging, since small animal models often fail to recapitulate human physiology. Hence, the comprehensive genetic and regulatory circuits driving the infection process of principal human pathogens such as Shigella flexneri remain to be defined.
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs - Nature Communications
Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation.
Teaching protein structure and function through molecular visualization
1 INTRODUCTION The three-dimensional (3D) structure of proteins defines their function. This 3D structure is determined by the physicochemical characteristics of the sequence of amino acids and interactions between their atoms. The structure of a protein can be experimentally resolved by using methods such as X-ray crystallography, nuclear magnetic resonance (NMR), or cryogenic electron microscopy (cryoEM).
Mechanical Loading Modulates AMPK and mTOR Signaling in Muscle Cells
Introduction Click to copy section linkSection link copied! Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).
Mechanical Loading Modulates AMPK and mTOR Signaling in Muscle Cells
Introduction Click to copy section linkSection link copied! Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).
Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains - Nature Communications
Abstract The function of many bacterial processes depends on the formation of functional membrane microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the mechanism and the biological function of these membrane microdomains remain unclear. Here, we show that FMMs in the pathogen methicillin-resistant Staphylococcus aureus (MRSA) are dedicated to confining and stabilizing proteins unfolded due to cellular stress.
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria
Abstract Nitroxoline is a bacteriostatic quinoline antibiotic, considered a metal chelator inhibiting the activity of RNA-polymerase. Its clinical indications are limited to uncomplicated urinary tract infections (UTIs), with a clinical susceptibility breakpoint only available for Escherichia coli.
Mechanical loading modulates AMPK and mTOR signaling in myblasts
Abstract Skeletal muscle adaptation to exercise involves various phenotypic changes that enhance metabolic and contractile functions. One key regulator of these adaptive responses is the activation of AMPK, influenced by exercise intensity. However, the mechanistic understanding of AMPK activation during exercise remains incomplete. In this study, we utilized an in vitro model to investigate the effects of mechanical loading on AMPK activation and its interplay with the mTOR signaling pathway.
d-amino acids signal a stress-dependent run-away response in Vibrio cholerae - Nature Microbiology
Abstract To explore favourable niches while avoiding threats, many bacteria use a chemotaxis navigation system. Despite decades of studies on chemotaxis, most signals and sensory proteins are still unknown. Many bacterial species release d-amino acids to the environment; however, their function remains largely unrecognized. Here we reveal that d-arginine and d-lysine are chemotactic repellent signals for the cholera pathogen Vibrio cholerae.
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems - Nature
Abstract Retrons are prokaryotic genetic retroelements, encoding a reverse transcriptase (RT) that produces multi-copy single-stranded DNA (msDNA1). Despite decades of research on msDNA biosynthesis2, the function and physiological role of retrons remained elusive. We show that Retron-Sen2 of Salmonella Typhimurium encodes an accessory toxin protein, which we rename RcaT. RcaT is neutralized by the RT-msDNA antitoxin complex, becoming active upon perturbations of msDNA biosynthesis.
Discover New Digital Comics on comiXology
Discover New Digital Comics on comiXology Posted on November 11, 2021 by Graphic Policy Team It’s a new day and comiXology has you covered with new comic releases. Check the releases out below or start shopping now! Aleister Crowley: Art of the Waste Written by RH Stewart Art by RH Stewart Purchase In 2009 Roy Huteson Stewart set out on an expedition into unknown realms to chronicle the life and times of the so-called “wickedest man in the world”.
Drug Target Identification in Tissues by Thermal Proteome Profiling
Annual Review of Pharmacology and Toxicology Vol. 62:- (Volume publication date January 2022) Review in Advance first posted online on September 9, 2021. (Changes may still occur before final publication.) https://doi.org/10.1146/annurev-pharmtox-052120-013205 André Mateus,1* Nils Kurzawa,1,2* Jessica Perrin,3 Giovanna Bergamini,3 and Mikhail M.
The functional proteome landscape of Escherichia coli
Abstract Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3,4,5,6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar phenotypic changes across several perturbations (chemical, environmental or genetic) when knocked out7,8,9. However, owing to the large number of perturbations, these approaches have been limited to growth or morphological readouts10.
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance
Highlights • SCH-79797 kills Gram-negative and Gram-positive bacteria with undetectable resistance • It works by simultaneously targeting folate metabolism and membrane integrity • SCH’s dual-targeting is synergistic, but only when on the same chemical scaffold • Irresistin-16, an SCH derivative, effectively treats mouse N. gonorrhoeae infection Summary The rise of antibiotic resistance and declining discovery of new antibiotics has created a global health crisis.
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
Abstract Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic polymorphisms to protein structures and identify 45 nsSNVs (non-synonymous small nucleotide variations) near the catalytic sites of 17 enzymes frequently lost in cancer.
The functional landscape of the human phosphoproteome
Abstract Protein phosphorylation is a key post-translational modification regulating protein function in almost all cellular processes. Although tens of thousands of phosphorylation sites have been identified in human cells, approaches to determine the functional importance of each phosphosite are lacking. Here, we manually curated 112 datasets of phospho-enriched proteins, generated from 104 different human cell types or tissues.
Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
Numerous factors can affect. These include drug transporters and drug-metabolizing enzymes, (3,5−7) sequestration of the drug into organelles (usually endolysosomes or mitochondria), (8,12−14) and the degree of binding to cellular components, such as lipids and proteins. This binding occurs mostly nonspecifically to the cell membranes involved in lipid partitioning.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with André
Contact André, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack