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Frank N Stein on Muck Rack

Frank N Stein

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Articles

A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites

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By Andrés Guillén-Samander, Hannah Behrens, Joëlle Paolo Mesén-Ramírez, Per Haberkant, Frank N Stein, Tobias Spielmann, Nika Perepelkina, Hely O. Rodriguez Cruz, Ana Ribeiro-Holbein
| Nature Verified
Abstract Malaria blood stages build and maintain an intricate system of membranes during their cycle of rapid growth and schizogony (daughter-cell formation), requiring precise mechanisms of lipid synthesis and trafficking. Lipid transfer proteins (LTPs) at ER membrane contact sites (MCSs) have emerged as key for lipid distribution processes but remain largely unexplored in protozoans. Here we use the ER adapter VAP to identify essential mechanisms of lipid transfer at ER-MCSs in P. falciparum.
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Molecular dynamics of the matrisome across sea anemone life history

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By Bruno Gideon Bergheim, Alison Cole, Mandy Rettel, Frank N Stein
| eLife
eLife Assessment This valuable study provides a comprehensive description of the Nematostella vectensis matrisome - the genes encoding the proteins of the extracellular matrix. The authors combine new mass spectrometry data with bioinformatic analyses of previously published genomic and single-cell RNAseq data. The analysis is thorough, and the discussion and conclusions are convincing.
Open in Who Shared View Duplicates (3) Issue with article?

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

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By Hiroyuki Uechi, Sindhuja Sridharan, Jik Nijssen, Jessica Bilstein, Juan M. Iglesias-Artola, Thom Doeleman, Sukhleen Kour, Frank N Stein, Xiaojie Zhang, Anastasia C. Murthy, Simon Alberti, Marc Bickle, Nicolas L. Fawzi, André Nadler, Della C. David, Udai B. Pandey, Florian Stengel, Benjamin Davis, Andrew Baldwin, Mikhail M. Savitski, Anthony A Hyman, Virginia Casablancas-Antras
| Nature Verified
Abstract Neurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule proteins. Aberrant stress granule condensate formation is associated with disease, making it a potential target for pharmacological intervention. Here, we identified lipoamide, a small molecule that specifically prevents cytoplasmic condensation of stress granule proteins.
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