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Articles by André Schultz
Advancing equity: six-year respiratory outcomes in young Indigenous children following early respiratory disease detection
Key words Indigenous Children Respiratory Bronchiectasis chronic wet cough Get full text access Log in, subscribe or purchase for full access. References 1. Chang, A.B. ∙ Bush, A. ∙ Grimwood, K. Bronchiectasis in children: diagnosis and treatment Lancet. 2018; 392(10150):866-879 2. Marsh, R.L. ∙ Binks, M.J. ∙ Smith-Vaughan, H.C. ...
Adherence to Anti‐Staphylococcal Prophylaxis in the First Two Years of Life and Microbiological Outcomes in the First Six Years of Life in Children With Cystic Fibrosis
Objective To assess the relationship between adherence to anti-staphylococcal prophylaxis with amoxycillin-clavulanic acid in the first 2 years of life in children with cystic fibrosis (CF) and microbiological outcomes in the first 6 years of life. Methods We conducted a retrospective cohort study of adherence to antistaphylococcal prophylaxis in children diagnosed with cystic fibrosis between 2000 and 2014 in Western Australia.
BEAT-CF (Bayesian Evidence Adaptive Treatment for people with Cystic Fibrosis): description of a prospective cohort for nested studies in cystic fibrosis
aHealth and Clinical Analytics, Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia bWesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, Perth, Western Australia, Australia cCentre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia dInfection, Immunity and Global Health Theme, Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, Victoria,...
Causal Bayesian networks to quantify the interactions that influence implementation success
The authors have declared no competing interest. The project was funded through a National Health and Medical Research Council Partnership Grant GTN1170735 and a Medical Research Future Fund Investigator Grant MRF1193796. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Learning to make a difference for chILD: Value creation through network collaboration and team science
1 INTRODUCTION Individually rare, but collectively common, rare diseases (defined as a prevalence of less than 1 in 2000) cause significant challenges to the health and well-being of individuals and families and can be difficult for health professionals to identify and manage.1, 2 Internationally, there are shortcomings and inequities in the provision of healthcare for people living with rare disease, which are further magnified in large countries with a relatively small,...
Improving screening in a paediatric cohort for cystic fibrosis‐related diabetes: A quality improvement project
To the Editor, Annual oral glucose tolerance testing (OGTT) is recommended for people with cystic fibrosis (CF) 10 years and older.1, 2 If an OGTT is abnormal further steps are required to diagnose CFRD, input from an endocrinologist with expertise in CFRD is recommended. Further investigations may involve repeat OGTT, HbA1c, random plasma glucose and/or continuous glucose monitoring. OGTT has many drawbacks as a screening test, has practical limitations, and is not desirable to many patients.
Keeping sputum induction safe with new position statement - InSight+
A new position statement from the Thoracic Society of Australia and New Zealand provides up-to-date guidelines for safely performing sputum induction. Sputum induction is widely used in health practice to obtain samples from the lower airways, typically for investigation of infection and inflammation. Common clinical indications include microbial surveillance in cystic fibrosis and other pulmonary infections, diagnosis of tuberculosis and monitoring airway inflammation.
The SPEC score-A quantifiable CT scoring system for primary ciliary dyskinesia
1 INTRODUCTION Primary ciliary dyskinesia (PCD) is a rare genetic disease, occurring between 1 in every 7000–10,000 live births in most communities, characterized by defects in the motile cilia lining the respiratory tract and other organs.1 In PCD, cilial ultrastructural deficiencies lead to poorly motile cilia, which, in turn, result in reduced mucous clearance in the lungs and upper airways.
Adherence to CF treatment can be improved with the right approach!
Adherence to CF treatment can be improved with the right approach! André Schultz1,2,3 1 Department of Respiratory Medicine, Perth Children's Hospital, Perth, Western Australia, Australia 2 Wal-yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia 3 Division of Paediatrics, Faculty of Medicine, University of Western Australia, Perth, Western Australia, Australia Correspondence to Dr André Schultz, Department of...
Inferring gene expression from cell-free DNA fragmentation profiles - Nature Biotechnology
Abstract Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for noninvasive cancer detection. Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current fragmentomic methods require high concentrations of tumor-derived DNA and provide limited resolution. Here we describe promoter fragmentation entropy as an epigenomic cfDNA feature that predicts RNA expression levels at individual genes.
Paediatric headbox as aerosol and droplet barrier
Paediatric headbox as aerosol and droplet barrier Free http://orcid.org/0000-0001-9471-8854Monica Sahih1, André Schultz2, Andrew Wilson3, Renuka Alakeson4, Ellen Taylor1, Benjamin Mullins5, Andrew C Martin1 1 Department of General Paediatrics, Perth Children's Hospital, Perth, Western Australia, Australia 2 Telethon Kids Institute, Wal-yan Respiratory Research Centre, Perth, Western Australia, Australia 3 Department of Respiratory Medicine, Perth Children's Hospital, Perth, Western Australia,...
Adherence to CF treatment can be improved with the right approach!
Adherence to CF treatment can be improved with the right approach! André Schultz1,2,3 1Department of Respiratory Medicine, Perth Children's Hospital, Perth, Western Australia, Australia 2Wal-yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia 3Division of Paediatrics, Faculty of Medicine, University of Western Australia, Perth, Western Australia, Australia Correspondence to Dr André Schultz, Department of Respiratory...
Paediatric headbox as aerosol and droplet barrier
Paediatric headbox as aerosol and droplet barrier Free http://orcid.org/0000-0001-9471-8854Monica Sahih1, André Schultz2, Andrew Wilson3, Renuka Alakeson4, Ellen Taylor1, Benjamin Mullins5, Andrew C Martin1 1Department of General Paediatrics, Perth Children's Hospital, Perth, Western Australia, Australia 2Telethon Kids Institute, Wal-yan Respiratory Research Centre, Perth, Western Australia, Australia 3Department of Respiratory Medicine, Perth Children's Hospital, Perth, Western Australia,...
A Step-by-Step Guide to Installing Packaging Machinery
Photo credit: DedMityay – adobe.stock.com You can ensure a smooth installation by understanding where to start and by following these tips at each stage of the process. Andre Schultz | Apr 06, 2021 Installing new packaging machinery provides a variety of advantages and opportunities to brand owners, but it also comes with an equally variety of challenges.
A wet cough for four weeks means it's time to get it checked out
Credit: Joshya/Shutterstock As respiratory clinicians, we have been conducting outreach clinics to the Kimberley, in northern Western Australia, for about ten years, treating children with bronchiectasis, a chronic lung disease in which the breathing tubes in the lungs are damaged. If left untreated, bronchiectasis can eat away at the lungs and cause devastating long-term effects.
A wet cough for four weeks means it's time to get it checked out
As respiratory clinicians, we have been conducting outreach clinics to the Kimberley, in northern Western Australia, for about ten years, treating children with bronchiectasis, a chronic lung disease in which the breathing tubes in the lungs are damaged. If left untreated, bronchiectasis can eat away at the lungs and cause devastating long-term effects.
Cough swabs less useful but induced sputum very useful in symptomatic older children with cystic fibrosis
Microbiological surveillance continues to be an important aspect of cystic fibrosis care.1x1Smyth, AR, Bell, SC, Bojcin, S et al. European Cystic Fibrosis Society standards of care: best practice guidelines. J Cyst Fibros. 2014; 13: S23–S42Summary | Full Text | Full Text PDF | PubMed | Scopus (158) | Google ScholarSee all References, 2x2Elborn, JS. Cystic fibrosis. Lancet.
To track or not to track: wheeze phenotypes in preschool children
To track or not to track: wheeze phenotypes in preschool children Paul L.P. Brand, André Schultz European Respiratory Journal Apr 2018, 51 (4) 1800042; DOI: 10.1183/13993003.00042-2018
Humidified high-flow nasal cannula oxygen for bronchiolitis: should we go with the flow?
Despite living in an era of evidence-based medicine and austerity, where every health dollar must be justified, the use of humidified high-flow nasal cannula oxygen (HFNC) in children with bronchiolitis has become increasingly prevalent,1 with limited evidence to substantiate its clinical benefit or economic worth.
Airway surface liquid pH is not acidic in children with cystic fibrosis
A prospective study conducted at Princess Margaret Hospital for Children. The study subjects were children with CF between 1 and 6 years of age undergoing annual routine bronchoscopy as part of the Australian Early Surveillance Team for Cystic Fibrosis (AREST CF) programme—a clinical pulmonary surveillance programme in which children up to the age of 7 years undergo annual bronchoscopy and BAL for detection of infection.
Humidified high-flow nasal cannula oxygen for bronchiolitis: should we go with the flow?
Despite living in an era of evidence-based medicine and austerity, where every health dollar must be justified, the use of humidified high-flow nasal cannula oxygen (HFNC) in children with bronchiolitis has become increasingly prevalent,1 with limited evidence to substantiate its clinical benefit or economic worth.
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At Vivaldi, we believe in empowering users and working very closely with our community in our journey to build the most customizable web browser on Earth. As part of our fast-growing team of passionate individuals, you will play a key role in developing our user community, Vivaldi.net, as well as our company website Vivaldi.com. Vivaldi’s community is built on a complex system, and we need a practical, solution-oriented developer that will support its growth.
'Big data' drills down into metabolic details
HOUSTON - (March 9, 2016) - Rice University bioengineers have introduced a fast computational method to model tissue-specific metabolic pathways. Their algorithm may help researchers find new therapeutic targets for cancer and other diseases. Metabolic pathways are immense networks of biochemical reactions that keep organisms functioning and are also implicated in many diseases. They present the kind of challenges "big data" projects are designed to address.
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