Andrew Oberst

Keywords apoptosis necroptosis pyroptosis programmed cell death regulated cell death Introduction Regulated cell death (RCD, sometimes also referred to as “programmed cell death”) is an ancient and fundamental biological process. In multicellular organisms, superfluous cells must be eliminated during development and to maintain tissue homeostasis, while both multicellular and single-celled organisms may respond to infection by rapidly deleting infected cells to suppress pathogen spread.

Keywords West Nile virus RIG-I RIG-I-like receptors innate immunity antiviral response Introduction Flaviviruses are a global threat to public health, placing billions at risk of infection and causing over 400 million disease cases per year worldwide.1 The emerging neurotropic flavivirus, West Nile virus (WNV), is the leading cause of arboviral infections in the United States, with recurrent annual outbreaks, and poses an ever-expanding hazard as its vector range increases.2 During WNV...

Supplementary Materials MDAR Reproducibility Checklist References and notes 1 J. Rehwinkel, M. U. Gack, RIG-I-like receptors: Their regulation and roles in RNA sensing. Nat. Rev. Immunol. 20, 537–551 (2020). 2 R. Savan, M. Gale Jr., Innate immunity and interferon in SARS-CoV-2 infection outcome. Immunity 56, 1443–1450 (2023). 3 Y. J. Crow, J.-L. Casanova, Human life within a narrow range: The lethal ups and downs of type I interferons. Sci. Immunol. 9, eadm8185 (2024). 4 H. Kato, O. Takeuchi, S. Sato, M. Yoneyama, M.