Caleb Stokes

Keywords Zika virus congenital infection neurodevelopment neurovirology single-cell RNA sequencing neural stem cells congenital Zika syndrome innate immunity fetal immunology neuro-immunology Introduction Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that can cause fetal developmental anomalies known as congenital Zika syndrome (CZS) upon infection during pregnancy.

Keywords West Nile virus RIG-I RIG-I-like receptors innate immunity antiviral response Introduction Flaviviruses are a global threat to public health, placing billions at risk of infection and causing over 400 million disease cases per year worldwide.1 The emerging neurotropic flavivirus, West Nile virus (WNV), is the leading cause of arboviral infections in the United States, with recurrent annual outbreaks, and poses an ever-expanding hazard as its vector range increases.2 During WNV...

Abstract Zika virus (ZIKV) infection during pregnancy can lead to fetal brain infection and developmental anomalies collectively known as congenital Zika syndrome (CZS). To define the molecular features underlying CZS in a relevant human cell model, we evaluated ZIKV infection and neurodevelopment in primary fetal brain explants and induced pluripotent stem cell-derived mixed neural cultures at single cell resolution.