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Articles by Andy Golden
Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome
Abstract Timothy syndrome (TS) is a multisystem disorder with autistic-like features, seizures and life-threatening arrhythmias. Most TS cases are caused by a de novo missense mutation in the CACNA1C gene that encodes the pore-forming subunit of the voltage-gated L-type calcium channel CaV1.2. Patients show highly variable clinical presentations and survival, which may be impacted by acute episodes of hypoglycemia and respiratory dysfunction.
Trends from Wynter’s New Report: How B2B SaaS Marketing Leaders Buy Software in 2024
B2B buying behaviors are constantly evolving, with review sites – like G2 – playing a more pivotal role in the buyer's journey. A new study from Wynter, based on the survey responses of 100 B2B SaaS marketing executives, sheds light on this phenomenon. According to the responses, 81% check out third-party reviews when vetting software.
Buyer Intent Data: Identify and Prioritize Sales-Ready Accounts
It’s no secret that B2B marketing teams are being held accountable for their influence on the pipeline more than in the recent past. B2B marketers need an efficient approach to make every dollar count toward revenue. In fact, surveys about the most significant changes in the role of the CMO find that now 47% of CMOs are expected to demonstrate their bottom line impact while as many as 40% are expected to prove marketing ROI with superhuman speed.
Identification of Genetic Suppressors for a Berardinelli-Seip Congenital Generalized Lipodystrophy Type 2 (BSCL2) Pathogenic Variant in C. elegans
Abstract Maintaining the metabolic homeostasis of fatty acids is crucial for human health. Excess fatty acids are stored in lipid droplets (LDs), the primary energy reservoir that helps regulate fat and lipid homeostasis in nearly all cell types. Seipin (BSCL2), a conserved endoplasmic reticulum protein, plays a critical role in LD biogenesis and regulating LD morphology.
a16z Podcast: Taking the Very, Very Long View on Tech Investing
It’s called “perpetual” or “eternal” capital, typically a very large pool of money invested on behalf of university endowments, foundations, and the like with a time horizon that extends generations into the future. The people who manage that money are driven by very different forces and thinking than your average Wall Street investor. Liquidity, for example, is not something this category of investors is immediately concerned with, nor are they swayed by your average economic cycle.
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