MATERIALS AND METHODS The EPIC-Skin trial (NCT05135052) is a prospective, multicenter, single-arm, open-label, phase IV study conducted at 7 sites worldwide: Australia (3 sites), South Africa (1 site), and Europe (Germany, Austria, and U.K., 1 site each). The objective is to assess clinic- and patient-reported outcomes of Rhenium SCT as a treatment for BCC and SCC. All patients will remain in the study for 24 mo from the time of their treatment with Rhenium SCT.