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Anish Hebbar on Muck Rack

Anish Hebbar

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Articles

Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMT networks

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By Anish Hebbar, Undergraduate Programme, Ankush Moger, Kishore Hari
| Cell Press Verified
Epithelial-mesenchymal plasticity (EMP) is a key arm of cancer metastasis and is observed across many contexts. Cells undergoing EMP can reversibly switch between three classes of phenotypes: epithelial (E), mesenchymal (M), and hybrid E/M. While a large number of multistable regulatory networks have been identified to be driving EMP in various contexts, the exact mechanisms and design principles that enable robustness in driving EMP across contexts are not yet fully understood.
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