Kishore Hari on Muck Rack

Kishore Hari

San Francisco
As seen in: PLOS, Frontiers, MDPI, PNAS, U.S. News and World Report, Mother Jones, Cell Press, Grist, GeekDad
@sciencequiche@sciencemastodon.com Community organizer for science @cziscience. @testedcom fam. Hockey lover. Herder of Nerds. Thanos forever.
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Articles

Impacts of competition and phenotypic plasticity on the viability of adaptive therapy

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By B Vibishan, Paras Jain, Vedant Sharma, Kishore Hari
| biorxiv.org
Abstract Cancer is heterogeneous and variability in drug sensitivity is widely documented across cancer types. Adaptive therapy is an emerging modality of cancer treatment that leverages this drug resistance heterogeneity to improve therapeutic outcomes. Current standard treatments typically eliminate a large fraction of drug-sensitive cells, leading to drug-resistant relapse due to competitive release.
Open in Who Shared Issue with article?

Critical assessment of the ability of Boolean threshold models to describe gene regulatory network dynamics.

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By Claus Kadelka, Kishore Hari
| biorxiv.org
Abstract The inference of gene regulatory networks (GRNs) from high-throughput data constitutes a fundamental and challenging task in systems biology. Boolean networks are a popular modeling framework to understand the dynamic nature of GRNs. In the absence of reliable methods to infer the regulatory logic of Boolean GRN models, researchers frequently assume threshold logic as a default.
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Topological conditions of gene regulatory networks enabling robust binary cell-fate decision-making

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By Sai Shyam, Mohit Kumar Jolly, Kishore Hari, Nikhil Nandan
| biorxiv.org
Abstract Embryonic development entails multi-layer branching of cell-fate decision processes; often, each branch corresponding to a binary cell-fate decision. The two phenotypes at such branching points usually have mutually exclusive gene expression patterns, driven by two master regulators that mutually inhibit each other and can activate themselves, forming a toggle switch.
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