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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
Main text (Cell Reports 35, 109291; June 29, 2021) There are errors in two figures of this paper. In Figure 6C, the p130Cas, total ERK, and phospho-p130Cas immunoblots inadvertently display alternative exposures from Figure 3D. In Figure S10B, images of four KX2-391-treated ex vivo tumors were inadvertently duplicated in the ERKi-treated ex vivo tumors.
γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis
Abstract A variety of physiological and pathological stimuli elicit the cellular senescence response. Immune cells are known to execute surveillance of infected, cancerous, and senescent cells, and yet senescent cells accumulate with age and drive inflammation and age-related disease. Understanding the roles of different immune cells in senescent cell surveillance could enable the development of immunotherapies against biological aging and age-related disease.
Inhibition of PIKfyve kinase induces senescent cell death by suppressing lysosomal exocytosis and leads to improved outcomes in a mouse model of idiopathic pulmonary fibrosis
Abstract Cellular senescence is a pivotal hallmark of aging, which limits lifespan and contributes to the development of age-related diseases. Efforts to identify senolytics - drugs that selectively eliminate senescent cells, have so far yielded candidates with limited translational potential. Here, we characterize the senescent cell surface proteomic landscape and identify proteins that are abnormally present on the plasma membrane of senescent cells.
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